Mechanism of the damage to myelinated axons in experimental Creutzfeldt-Jakob disease in mice: An ultrastructural study |
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Authors: | P. P. Liberski R. Yanagihara C. J. Gibbs Jr. D. C. Gajdusek |
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Affiliation: | (1) The Laboratory of the Central Nervous System Studies, National Institute of Neurological Disorders and Stroke - National Institutes of Health, 20892 Bethesda, MD, USA;(2) Medical Academy Lodz, Deptartment of Oncology - Electron Microscopic Laboratory Gagarina 4, Lodz, Poland |
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Abstract: | We report the ultrastructural pathology of myelinated axons in mice infected experimentally with the Fujisaki strain of Creutzfeldt-Jakob disease (CJD). Initially the myelin sheath was separated into several concentric bands, and cellular processes penetrated between layers of myelin and lifted away the outermost lamella. Then a complicated labyrinth of the concentric cellular processes, clearly belonging to either astrocytes or macrophages, invested myelinated axons. In terminal stages axons completely denuded of myelin were seen in the center of concentric networks of cellular processes. Myelin remnants were seen within astrocytes and macrophages. We conclude that the mechanism(s) of damage to myelinated axons in CID may be similar to that operating in immunologically mediated demyelinating disorders.Corresponding author. |
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Keywords: | Creutzfeldt-Jakob disease Electron microscopy Myelinated axon |
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