枢丹预防大剂量顺铂化疗所致呕吐的临床效果

目的观察枢丹的止吐疗效和毒性。方法对３０例接受大剂量顺铂化疗的患者,采用随机自身对照的方法,比较枢丹和枢复宁在相等剂量下的疗效和毒性。结果枢丹能有效预防顺铂所致的恶心、呕吐,其止吐效果与枢复宁相似。两药的止吐有效率分别为７０．０％和６３．３％,完全缓解率分别为５６．７％和５３．３％。两药的疗效无统计学差异,且毒副反应小。结论枢丹为肿瘤化疗安全、有效的止吐药,值得临床推广应用

A randomized trial of Zudan in the prophylaxis of nausea and vomiting induced by cisplatin

Objective To study the anti emetic effect of Zudan on high dose cisplatin and its toxicity. Methods A randomized, crossover assay was used in thirty patients who received cisplatin chemotherapy to compare the efficacy and the toxicity of identical dose of Zudan and Zofran. Results The response rate of acute vomiting induced by cisplatin was 70.0% in patients receiving Zudan and 63.3% in those receiving Zofran. Complete response rate was 56.7% in Zudan arm and 53.3% in Zofran arm. The two arms were not remarkably different in response rates or adverse reactions. Conclusion Zudan is safe and effective in the control of vomiting induced by cisplatin.