| PCNA和EMMPRIN在食管鳞癌中的表达及其临床意义 |
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| 引用本文： | 万勇,吴心愿.PCNA和EMMPRIN在食管鳞癌中的表达及其临床意义[J].肿瘤,2011,31(2):141-144. |
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| 作者姓名： | 万勇 吴心愿 |
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| 作者单位： | 福建医科大学附属协和医院胃外科,福州,350001 |
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| 摘 要： | 目的:探讨增殖细胞核抗原(proliferating cell nuclear antigen,PCNA)及细胞外基质金属蛋白酶诱导因子(extracellular matrix metalloproteinase inducer,EMMPRIN)在食管鳞状细胞癌组织中的表达及其临床意义。方法:采用免疫组织化学法检测PCNA和EMMPRIN在食管鳞癌组织和正常食管上皮组织中的表达水平,并结合临床病理资料进行统计学分析。结果:PCNA在食管鳞癌组织及癌旁正常组织中的表达率分别为61.25%和23.75%,EMMPRIN蛋白在食管鳞癌组织和癌旁正常组织中的表达率分别为57.5%和25.0%,差异均具有统计学意义(P=0.000)。PCNA和EMMPRIN蛋白的表达与食管鳞癌浸润深度、淋巴结转移、TNM分期、分化程度及患者生存时间有显著相关性(P<0.05)。PCNA和EMMPRIN高表达的食管鳞癌患者预后较差。结论:PCNA和EMMPRIN蛋白的表达与食管鳞癌的临床病理学特征密切相关,在食管鳞癌的发生、发展和淋巴结转移中发挥了一定的作用。
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| 关 键 词： | 食管肿瘤 增殖细胞核抗原 细胞外基质金属蛋白酶诱导因子 免疫组织化学 预后 |
Expressions of PCNA and EMMPRIN in esophageal squamous cell carcinoma and their clinical significance |
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| WAN Yong,WU Xin-yuan.Expressions of PCNA and EMMPRIN in esophageal squamous cell carcinoma and their clinical significance[J].Tumor,2011,31(2):141-144. |
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| Authors: | WAN Yong WU Xin-yuan |
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| Institution: | WAN Yong,WU Xin-yuan Department of Gastrosurgery,Union Hospital,Fujian Medical University,Fuzhou 350001,China |
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| Abstract: | Objective:To investigate the expressions of proliferating cell nuclear antigen(PCNA) and extracellular matrix metalloproteinase inducer(EMMPRIN) in esophageal squamous cell carcinoma tissues and their clinical significance.Methods:Immunohistochemistry method was used to detect the expressions of PCNA and EMMPRIN in esophageal squamous cell carcinoma tissues and the normal esophageal epithelial tissues.The correlations of the clinicopathological variables with the expressions of PCNA and EMMPRIN were evaluat... |
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| Keywords: | Esophageal neoplasms Proliferating cell nuclear antigen Extracellular matrix metalloproteinase inducer Immunohistochemistry Prognosis |
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