尿微量白蛋白与非糖尿病患者冠脉病变的相关性研究

目的 探讨非糖尿病冠心病（CHD）患者微量白蛋白尿和冠状动脉病变程度的相关性.方法 选择因疑诊CHD而行冠状动脉造影患者187例,以冠脉病变支数和Gensini评分系统评价冠状动脉病变程度,以晨尿白蛋白/肌酐比值（ACR）衡量尿微量白蛋白（MAU）.结果 MAU阴性者CHD发病率显著低于MAU阳性者（P＜0.01）,MAU阳性者出现1、2、3支冠脉病变率和冠脉病变血管支数、Gensini总积分均高于MAU阴性者（均P＜0.05） ACR值随着冠脉病变支数的增加而升高,且任意冠脉病变支数组之间ACR值的差异均有统计学意义（P＜0.01）.Pearson相关分析表明,ACR值与Gensini总积分存在正相关（r=0.593,P＜0.01）.结论 MAU定性和定量均能反映非糖尿病CHD患者冠状动脉病变的程度.

Microalbuminuia and severity of coronary artery stenosis in non-diabetic patients

Objective To explore the relationship between microalbuminuria and degree of coronary artery stenosis in patients with non-diabetic coronary heart disease （CHD）. Methods Coronary artery angiography was performed for 187 patients without diabetic mellitus who were suspected of CHD, the degree of coronary artery stenosis was evaluated by the numbers of stenotic coronary artery and Gensini scoring system. The morning urine albumin/creatinine ratio （ACR） was detected for microalbuminuria （MAU）. Results The incidence of CHD in patients with negative MAU was significantly lower than that in patients with positive MAU （P〈0.01）. Compared with negative MAU patients, positive MAU patients had significant higher rates of one, two, or three coronary artery stenosis, total numbers of stenotic coronary artery and Gensini total score, respectively（P〈0.05）. ACR value increased with the numbers of stenotic coronary artery. The difference of ACR between any two groups with different numbers of coronary artery stenosis were statistically significant （P〈0.01） respectively. Pearson correlation analysis indicated that ACR value was positively correlated with the total score of Gensini （r=0.593, P〈0.01）. Conclusion MAU could qualitatively and quantitatively reflect the severity of coronary artery stenosis in non-diabetic CHD patients.