| 大黄煎液对阿霉素肾病小鼠的治疗作用研究 |
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| 引用本文： | 陈汉卿,谢鑫灵,金笑笑,陈炳荣,蒋军,姚光校. 大黄煎液对阿霉素肾病小鼠的治疗作用研究[J]. 浙江中医药大学学报, 2011, 35(2): 291-293,296 |
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| 作者姓名： | 陈汉卿 谢鑫灵 金笑笑 陈炳荣 蒋军 姚光校 |
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| 作者单位： | 浙江中医药大学第一临床医学院,杭州,310053 |
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| 摘 要： | [目的]探讨大黄煎液对阿霉素肾病小鼠的治疗作用。[方法]建立阿霉素诱导的肾病模型,随机分为模型组、大黄煎液低剂量组、大黄煎液高剂量组、强的松治疗组及空白对照组。收集各组小鼠血液、24h尿液,检测其血、尿肌酐和尿蛋白含量;HE染色下观察肾脏病理学变化。[结果]实验第2周大黄煎液低剂量组尿蛋白含量比大黄煎液高剂量组和强的松组明显减少(P<0.05)。实验第4周大黄煎液高剂量组和强的松组血肌酐含量比空白组、模型组明显减少(P<0.05)。HE染色示模型组小鼠肾小球系膜部分增厚,细胞核增多,肾小管有充血。[结论]大黄煎液对阿霉素肾病小鼠具有一定治疗作用。
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| 关 键 词： | 大黄煎液 低剂量 高剂量 强的松 阿霉素肾病 |
Study of Therapeutical Effects of Rhubarb Apozem in Mice with Adriamycin Nephropathy |
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| Chen Hanqing,Xie Xinling,Jin Xiaoxiao,et al First Clinical Medical Institute of Zhejiang Chinese Medical University,Hangzhou. Study of Therapeutical Effects of Rhubarb Apozem in Mice with Adriamycin Nephropathy[J]. Journal of Zhejiang University of Traditional Chinese Medicine, 2011, 35(2): 291-293,296 |
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| Authors: | Chen Hanqing Xie Xinling Jin Xiaoxiao et al First Clinical Medical Institute of Zhejiang Chinese Medical University Hangzhou |
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| Affiliation: | Chen Hanqing,Xie Xinling,Jin Xiaoxiao,et al First Clinical Medical Institute of Zhejiang Chinese Medical University,Hangzhou(310053) |
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| Abstract: | [Objective]To observe the therapeutical effects of Rhubarb apozem in mice with Adriamycin nephropathy.[Methods]Adriamycin nephropathy mice models were prepared and randomly divided into model group,Rhubarb low dose group,Rhubarb high dose group,Prednisone treatment group and blank group.The blood and 24h urine volume of each group were collected to determine contents of serum and urine creatinine and contents of urine protein.One side of renal tissues was fixed to apply HE staining and pathological changes ... |
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| Keywords: | Rhubarb apozen low dose high dose Prednisone Adriamycin nephropathy |
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