| ErbB4基因micro-RNA靶序列单核苷酸多态性与乳腺癌易感性的关系 |
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| 引用本文： | 朱晓灵,宋丰举,郑红,张丽娜,赵妍蕊,陈可欣. ErbB4基因micro-RNA靶序列单核苷酸多态性与乳腺癌易感性的关系[J]. 肿瘤, 2011, 31(3): 233-238. DOI: 10.3781/j.issn.1000-7431.2011.03.009 |
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| 作者姓名： | 朱晓灵 宋丰举 郑红 张丽娜 赵妍蕊 陈可欣 |
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| 作者单位： | 天津医科大学附属肿瘤医院肿瘤研究所流行病室,乳腺癌防治教育部重点实验室,天津市"肿瘤防治"重点实验室,天津,300060 |
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| 基金项目： | 1.国家自然科学基金资助项目(编号:30872172)2.天津市科技计划项目 |
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| 摘 要： | 目的:探讨ErbB4基因micro-RNA靶序列单核苷酸多态性与乳腺癌易感性的关系。方法:采用TaqMan单核苷酸多态(single nucleotide polymorphism,SNP)分型技术检测1509例乳腺癌患者和1517例健康对照者外周血中ErbB4基因micro-RNA靶序列rs1595066及rs16845990位点的基因型。结果:ErbB4基因micro-RNA靶序列rs16845990位点3种基因型在乳腺癌患者和健康对照者间的分布差异无统计学意义(P=0.302);rs1595066位点3种基因型在2组间的分布差异有统计学意义(P=0.045),与GG型相比,杂合型AG及纯合型AA均可显著降低乳腺癌的发病风险,调整后比值比(oddsratios,OR)及其95%可信区间(confidenceintervals,CI)分别为0.81(0.69～0.95)和0.75(0.58～0.96)。分层分析显示,此保护作用在年龄≥55岁、无肿瘤家族史和无乳腺良性疾病史者中更显著。结论:ErbB4基因micro-RNA靶序列rs1595066G>A位点A等位基因可能降低乳腺癌的发病风险。
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| 关 键 词： | 乳腺肿瘤 微RNAs 多态性,单核苷酸 危险因素 |
Relationship between polymorphism of ErbB4 gene in mirco-RNA binding site and the risk for breast cancer |
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| ZHU Xiao-ling,SONG Feng-ju,ZHENG Hong,ZHANG Li-na,ZHAO Yan-rui,CHEN Ke-xin. Relationship between polymorphism of ErbB4 gene in mirco-RNA binding site and the risk for breast cancer[J]. Tumor, 2011, 31(3): 233-238. DOI: 10.3781/j.issn.1000-7431.2011.03.009 |
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| Authors: | ZHU Xiao-ling SONG Feng-ju ZHENG Hong ZHANG Li-na ZHAO Yan-rui CHEN Ke-xin |
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| Affiliation: | Department of Epidemiology,Cancer Institute;Key Laboratory of Breast Cancer Prevention and Therapy,Ministry of Education;Tianjin Key Laboratory of Cancer Prevention and Therapy,Tianjin Medical University,Tianjin 300060,China |
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