甘精胰岛素联合阿卡波糖治疗2型糖尿病疗效观察

目的：观察甘精胰岛素（来得时）联合阿卡波糖（拜唐萍）治疗2型糖尿病患者的临床疗效。方法：选取40例糖化血红蛋白（HbAlc）〉9％的2型糖尿病患者，予每餐口服阿卡波糖，同时每晚22点睡前皮下注射甘精胰岛素治疗3个月，观察治疗前后血糖水平、低血糖发生情况及体质指数（BMI）。结果：治疗后患者的空腹血糖（FPG）、餐后2h血糖（2hPO）、HbAlc较治疗前均显著下降（P〈0．05）；体质指数（BMI）治疗前后无显著性差异（P〉0．05）；低血糖发生率为2．5％。结论：甘精胰岛素联合阿卡波糖能有效降低糖化血红蛋白（HbAlc）〉9％的2型糖尿病患者的血糖，且对体重影响较小，具有安全、方便、依从性高的特点，可作为临床2型糖尿病的治疗方案。

Clinical Observation of Glargine Combined with Acarbose Tablets in Treating Newly Diagnosed Type 2 Diabetes Patients

Objective. To observate the Clinical effect of glargine combined with acarbose tablets in treating newly diagnosed type 2 diabetes patients. Methods. fourty newly diagnosed type 2 diabetic patients（HbAlc〉9% ） were treated acarbose at each meal, bedtime subcutaneous injection of insulin glargine for 3 months. Blood glucose level, body mess index（BMI） and incidence of hypoglycemia were observed. Results： The fasting blood glucose, post prandial two hour blood glucose, glycosylated hemoglobin were obviously decreased after treatment as com- pared with their pre-treatment , there was no significant difference in BMI before and after treatment. The incidence of hypoglycemia was 2. 5 ~. Conclusion.Glargine plus acarbose can effectively reduce blood glucose of glycated hemoglobin （HbAlc）〉 9% newly diagnosed pa- tients with type 2 diabetes, with lower incidence of hypoglycemia and minimal effect on BMI. The ther-apeutic regimen is safe, convenient with patient compliance and can be applied to clinical therapy of type 2 diabetes mellitus.