复发性流产与自身免疫性抗体的相关性研究

目的探讨复发性流产（RSA）与5种自身免疫性抗体的相关性。方法采用酶联免疫吸附试验对186例RSA妇女（流产组）和100例正常妊娠妇女（对照组）进行血清抗心磷脂抗体（ACAb）、抗卵巢抗体（AOAb）、抗精子抗体（ASAb）、抗子宫内膜抗体（EMAb）及抗绒毛膜促性腺激素抗体（HCGAb）的检测并加以比较分析。结果流产组妇女ACAb、AOAb、ASAb、EMAb和HCGAb的检出率分别为45．7％（85例）、29．6％（55例）、26．9％（50例）、43．0％（80例）和25．8％（48例），明显高于对照组的6．O％（6例）、2．0％（2例）、5．0％（5例）、2．0％（2例）和4．0％（4例）（均P〈0．01）。流产3、4、5次的5种抗体检出率明显高于流产2次者，差异均有统计学意义（P〈0．05或P〈0．01）。结论ACAb、AOAb、ASAb、EMAb、HCGAb与RSA有明显的关系，是造成RSA的重要因素，进行这5种自身免疫性抗体的检测，对RSA的临床诊治有指导意义。

Analysis of autoantibodies related to recurrent spontaneous abortion

Objective To investigate the relation between recurrent spontaneous abortion（RSA） and au- toantibodies. Methods Serum anticardiolipin antibody（ ACAb）, antiovarian antibody（ AOAb）, antisperm antibody （ ASAb）, antiendometrial antibody（EMAb） and anti-HCG antibody（HCGAb） of 186 cases with recurrent spontane- ous abortion （abortion group） and 100 normal controls （control group） were detected. Results The positive rates of ACAb, AOAb, ASAb, EMAb and HCGAb in abortion group were 45.7% （85 cases）, 29.6% （55 cases）, 26.9% （50 cases）, 43.0% （80 cases） and 25.8% （48 cases） respectively, while 6.0% （6 cases）, 2.0% （2 cases）, 5.0% （5 cases）, 2.0% （2 cases） and 4.0% （4 cases） in control group. There was significant difference between two groups（ all P 〈0.01 ）. The positive rates of these five antibodies in abortion three, four and five times patients were higher than abortion two times patients, and there were significant differences （ P 〈 0. 05 or P 〈 0.01 ）. Conclusions ACAb, AOAb, ASAb, EMAb, HCGAb are all related to RSA. Detection of the above five antibodies can help diagnosis and treatment of RSA.