肝型脂肪酸结合蛋白与非酒精性脂肪性肝病严重程度及其他指标关系探讨

目的 探讨血清肝型脂肪酸结合蛋白（L-FABP）与非酒精性脂肪性肝病（NAFLD）患者疾病严重程度及脂代谢相关临床生化指标的相互关系.方法 选择96例NAFLD患者（观察组）及100例健康体检者（对照组）,用酶联免疫吸附法测定血清L-FABP及血生化指标,超声判定病变程度,同时计算体质指数（BMI）、腰臀比（WHR）及稳态模型评估法胰岛素抵抗指数（HOMA-IR）.结果 观察组WHR、BMI、空腹血糖（FBG）、三酰甘油（TG）、丙氨酸氨基转移酶（ALT）、HOMA-IR及L-FABP水平明显高于对照组,差异均有统计学意义（P＜0.05）.相关性分析结果表明,L-FABP水平与ALT（r=0.735）、TG（r=0.728）、FBG（r=0.681）、WHR（r=0.713）、BMI（r=0.699）、HOMA-IR（r=0.673）均呈正相关（P＜0.05）,与HDL-C呈负相关（r=-0.607,P＜ 0.05）.对照组L-FABP水平为（15.42±2.51） g/L,轻度NAFLD为（15.96±2.92） g/L,中度NAFLD为（17.48±3.91） g/L,重度NAFLD为（25.14±5.37） g/L.重度NAFLD患者L-FABP水平与对照组及轻、中度NAFLD患者比较差异均有统计学意义（P＜0.05）.结论 重度NAFLD患者血清L-FABP水平明显增高,L-FABP水平与一些肝功能生化指标有关.

Correlation between fiver-type fatty acid binding protein and nonalcoholic fatty fiver disease extent and other clinical parameters

Objective To investigate the correlation between liver-type fatty acid binding protein （L-FABP） and nonalcoholic fatty liver disease （NAFLD） extent and other clinical parameters.Methods Ninety-six patients of NAFLD （NAFLD group） and 100 cases of healthy controls （control group） were selected.The levels of serum L-FABP and blood biochemical parameters were measured by enzyme-linked immunosorbent assay.The lesion degree was assessed by ultrasound.The body mass index （BMI）,waist to hip ratio （WHR） and homeostasis model assessment insulin resistance index （HOMA-IR） were calculated.Results The WHR,BMI,fasting plasma glucose （FBG）,triglycerides （TG）,alanine aminotransferase （ALT）,HOMA-IR and L-FABP in NAFLD group were higher than those in control group,there were statistical differences （P 〈 0.05）.The result of correlation analysis showed L-FABP level was positively related with ALT,TG,FBG,WHR,BMI,HOMA-IR （r =0.735,0.728,0.681,0.713,0.699,0.673 ;P 〈0.05）,and negative correlation with HDL-C （r =-0.607,P 〈 0.05）.The L-FABP level in control group was （15.42 ± 2.51） g/L,mild NAFLD was （15.96 ± 2.92） g/L,moderate NAFLD was （17.48 ± 3.91） g/L,serious NAFLD was （25.14 ± 5.37） g/L.There was statistical difference in L-FABP level between serious NAFLD and control group,mild NAFLD,moderate NAFLD （P 〈 0.05）.Conclusion Serum L-FABP level of serious NAFLD patient significantly increases,and L-FABP level is related with biochemical parameters of liver function.