促泌素在神经内分泌肿瘤中的表达及检测意义

目的探讨促泌素（SCGN）在神经内分泌肿瘤中的表达及临床意义。方法采用免疫组织化学法检测45例神经内分泌肿瘤组织中SCGN、嗜铬素A（CgA）、突触素（Syn）、神经元特异性烯醇化酶（NSE）的表达，观察SCGN与其他三者表达的差异；并比较SCGN在不同性别、年龄及肿瘤分级的神经内分泌肿瘤中的表达差异。结果在神经内分泌肿瘤组织中SCGN、Syn、CgA、NSE的阳性表达率分别为95．56％（43／45）、100．00％（45／45）、46．67％（21／45）、88．89％（40／45），差异有统计学意义（P〈0．01），SCGN在不同性别、年龄及肿瘤分级中的表达比较差异无统计学意义（P〉0．05）。结论在绝大多数神经内分泌肿瘤组织中SCGN呈阳性表达，且表达敏感度要高于CgA；Syn是诊断神经内分泌肿瘤最敏感的指标；SCGN可作为一个新的神经内分泌标记物用于临床神经内分泌肿瘤的诊断。

Expression and significance of secretagogue in neuroendocrinal tumors

Objective To explore the expression and clinical significance of secretagogne （SCGN） in neuroendocrinal tumors. Methods Immunohistochemistry was applied for detecting expression of SCGN, chromogranin A （CgA）,synaptophysin （Syn） and neuronspecific enolase （NSE） in 45 cases of neuroendocrinal tumors. The difference between the expression of SCGN and the remaining indicators were compared. And different expression profiles of SCGN between groups categorized by sex, age and degree of differentiation were also compared. Results The positive expression rate of SCGN,CgA,Syn and NSE in neuroendoerinal tumors was 95.56% （43/45）, 100.00% （45/45） ,46.67 % （21/45） and 88.89% （40/45） respectively, and the differences among them were statistieally significant（P 〈 0.01 ）. Expression of SCGN was not correlated with the patient＇ s sex, age and degree of differentiation （P 〉 0.05 ）. Conclusions Most eases of neuroendocrinal tumors are positive for SCGN and SCGN is more sensitive than CgA. Syn is the most sensitive one for diagnosis of neuroendoerinal tumors. SCGN can be seen as a novel neuroendocrinal marker in the clinical diagnosis of neuroendocrinal tumors.