两种不同慢性应激对大鼠体质量与自发活动的影响

目的：观察慢性束缚性应激与不可预测应激对大鼠体质量与自发活动的影响。方法：大鼠随机分成对照组、慢性束缚性应激组（接受21d束缚应激）和慢性不可预测应激组（接受21d不可预测应激）。用电子动物秤称大鼠体质量,开场实验测定大鼠自发活动。结果：①第7d,对照组与慢性不可预测应激组体质量增长无统计学意义,慢性束缚性应激组体质量增长明显低于对照组和慢性不可预测应激组（P〈0.01）。第14、21d,两个应激组体质量增长明显低于对照组（P〈0.01）。②经21d应激,慢性不可预测应激组的中央路程和中央活动时间均明显少于对照组和慢性束缚性应激组（P〈0.05）,活动总路程大幅减少（P〈0.01）;慢性束缚性应激组与对照组比,总路程、中央路程与中央活动时间均无统计学意义。结论：慢性束缚性应激与不可预测应激均导致大鼠体质量增长减少,而慢性不可预测应激引起大鼠自发活动减少,行为受抑制。

Influence of Different Chronic Stress Body Weight and Locomotion Activity in Rats

Objective：To observe the influence of chronic restraint stress and unpredictable stress on body weight and locomotion activity in rats. Method：The rats were allocated into control,chronic restraint stress and unpredictable stress groups. Electronic animal scale was used to weigh the rats. The locomotion activity was determined by animal behavior analysis system. Results：On day7,there was no statistical significance in the body weight gain between control group and unpredictable stress group,the body weight gain in the restraint stress group was lower than that in the control group and unpredictable stress group（P〈0.01）. On day14 and day21,the body weight gain in restraint and unpredictable stress groups was lower than that in control group（P〈0.01）. The central distance,movement time and total distance in the chronic unpredictable stress group were lower than those in the control group and chronic restraint stress group（P〈0.05,P〈0.01）by day21 stress. Compared with the control group,there were no statistical significances in the total distance,central distance and movement time in the chronic restraint stress group. Conclusion：The chronic restraint stress and unpredictable stress can suppress body weight gain in rats. The chronic unpredictable stress can decrease locomotion activity in rats,and the behavior can be suppressed.