Induction of sharp wave-ripple complexes in vitro and reorganization of hippocampal networks |
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Authors: | Behrens Christoph J van den Boom Leander P de Hoz Livia Friedman Alon Heinemann Uwe |
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Affiliation: | Institute for Neurophysiology, Charité-Universit?tsmedizin Berlin, Tucholskystrasse 2, 10117 Berlin, Germany. |
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Abstract: | Hippocampal sharp wave-ripple complexes (SPW-Rs) occur during slow-wave sleep and behavioral immobility and are thought to represent stored information that is transferred to the neocortex during memory consolidation. Here we show that stimuli that induce long-term potentiation (LTP), a neurophysiological correlate of learning and memory, can lead to the generation of SPW-Rs in rat hippocampal slices. The induced SPW-Rs have properties that are identical to spontaneously generated SPW-Rs: they originate in CA3, propagate to CA1 and subiculum and require AMPA/kainate receptors. Their induction is dependent on NMDA receptors and involves changes in interactions between clusters of neurons in the CA3 network. Their expression is blocked by low-frequency stimulation but not by NMDA receptor antagonists. These data indicate that induction of LTP in the recurrent CA3 network may facilitate the generation of SPW-Rs. |
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