鲍曼不动杆菌在ICU的感染分布与耐药分析

目的 探讨医院ICU科室内鲍曼不动杆菌(Acinetobacter Baumannii,AB)感染情况以及对抗菌药物的耐药情况,为临床抗生素的使用及医院感染控制提供依据.方法 回顾性分析2015年6月至2016年6月本院中心ICU患者不同送检标本中AB菌的分布及其对14种抗生素的耐药情况,并利用WHONET5.6及SPSS22.0软件进行统计学分析.结果 痰标本中检测出AB菌286株,占总检测样本的79.5％,其中检出多重耐药菌株201株,占AB菌株的70.3％;药敏试验结果显示,所分离鉴定出的AB菌对多粘菌素B的耐药性较低(19.82％),而对其他抗菌药物的耐药性均较高.结论 ICU患者的标本AB菌对常用抗菌药物的获得性耐药率极高,且检出的AB菌株中多重耐药菌株占有极高比例,临床应更加合理使用抗生素,加强病原学监测、注意环境卫生和尽量减少介入性治疗,以减少AB菌感染及AB菌耐药性的增强.

Analysis of distribution and drug resistance of Acinetobacter Baumannii infection in ICU

Objective To investigate the infection and drug resistance ofAcinetobacter Baumannii (AB) in intensive care unit (ICU) of our hospital and provide a gist for clinical rational administration of antibiotics and control of hospital infection.Methods From June 2015 to June 2016,we retrospected the distribution and drug resistance for 14 antibiotics of AB in various specimens in ICU.The data were processed by WHONET5.6 and SPSS22.0 statistic software.Results Two hundred and eighty-six AB strains were detected in sputa,accounting for 79.5％ of all specimens.Among of them,multi-drug resistant AB strains were 201,accounting for 70.3％ of all strains.Drug sensitivity test showed that the isolated AB had low resistance to Polymyxin B (19.82％),but relatively high resistance to the other antibiotics.Conclusion The AB strains in ICU have extremely high resistance to common antibiotics and extremely high proportion in multiple drug resistance.The administration of clinical antibiotics should be more reasonable.To strengthen pathogen monitoring,pay attention to environmental sanitation and minimize interventional therapy,we can reduce the opportunity of AB infection and capacity of drug resistance.