亚砜咪唑与诺森治疗消化性溃疡合并出血的临床效果

目的 探讨亚砜咪唑与诺森治疗消化性溃疡合并出血的临床效果.方法 选择本院2013年6月至2014年6月收治的消化性溃疡伴出血患者100例,其中92例幽门螺旋杆菌感染,将该92例设为对照组,在一般对症治疗基础上给予亚砜咪唑;另选择本院2014年7月至2015年12月收治的消化性溃疡伴出血患者100例,其中89例幽门螺旋杆菌感染,将该89例设为观察组,在一般对症治疗基础上给予诺森;观察两组治疗效果.结果 观察组和对照组总有效率分别为89.9％和67.4％,组间比较,差异有统计学意义(P＜ 0.05);观察组幽门螺旋杆菌感染率由100.0％下降至2.2％,对照组由100.0％下降至16.3％,观察组改善效果更加显著,组间比较,差异有统计学意义(P＜0.05);观察组治疗后VAS评分为(2.1±0.2)分,对照组VAS评分为(3.3±0.6)分,组间比较,差异有统计学意义(P＜0.05);两组pH值均明显升高,但观察组更趋于正常值,效果更理想,组间比较,差异有统计学意义(P＜0.05);观察组和对照组幽门螺旋杆菌清除率分别为86.5％和51.1％,组间比较,差异有统计学意义(P＜0.05);观察组和对照组不良反应发生率分别为9.0％和4.3％,观察组略高,但组间比较,差异无统计学意义(P＞0.05).结论 诺森治疗消化性溃疡合并出血可有效抑制胃酸分泌,清除幽门螺旋杆菌,安全性高,优于亚砜咪唑,效果确切.

Omeprazole and innocent in treatment of peptic ulcer complicating hemorrhage

Objective To investigate the clinical effect of omeprazole and innocent in the treatment of peptic ulcer complicating hemorrhage.Methods 100 patients with peptic ulcer complicating hemorrhage treated at our hospital from June,2013 to June,2014 were selected;among which,92 cases were infected by helicobacter pylori and were set as a control group and were symptomatically treated and were treated with omeprazole.Another 100 patients with peptic ulcer complicating hemorrhage treated at our hospital from July,2014 to December,2015 were selected;among which,89 cases were infected by helicobacter pylori and were set as an observation group and were symptomatically treated and were treated with innocent.The treatment effects of the two groups were observed.Results The total effective rate was 89.9％ in the observation group and was 67.4％ in the control group,with a statistical difference (P ＜ 0.05).The helicobacter pylori infection rate decreased from 100.0％ to 2.2％ in the observation group and from 100.0％ to 16.3％ in the control group,with a statistical difference (P ＜ 0.05).The VAS score after the treatment was (2.1±0.2) in the observation group and was (3.3±0.6)in the control group,with a statistical difference (P ＜ 0.05).The pH value increased in both groups and was closer to normal value in the observation group than in the control group,with a statistical difference (P ＜ 0.05).The clearance rate of helicobacter pylori was 86.5％ in the observation group and was 51.1％ in the control group,with a statistical difference (P ＜ 0.05).The incidence of adverse reactions was 9.0％ in the observation group and was 4.3％ in the control group,with no statistical difference (P ＞ 0.05).Conclusions Innocent in the treatment of peptic ulcer complicating hemorrhage can effectively inhibit the secretion of gastric acid and clear helicobacter pylori and is safe and more effective than omeprazole.