缬沙坦联合阿托伐他汀对老年单纯收缩期高血压治疗效果分析

目的 探讨缬沙坦联合阿托伐他汀应用在老年单纯收缩期高血压患者中的临床疗效及应用价值.方法 将本院治疗的单纯收缩期高血压老年患者150例采用随机数字法分为观察组和对照组,每组75例,对照组给予缬沙坦治疗,观察组联合阿托伐他汀治疗,记录两组临床疗效.结果 观察组干预后收缩压为(125.28±4.16) mmHg(1mmHg=0.133 kPa),舒张压为(72.32±3.28) mmHg,脉压为(57.36±2.33)mmHg,显著优于对照组[分别为(135.38±8.21)mmHg、(79.66±5.43) mmHg、(67.76±3.88)mmHg],均P＜0.05.观察组干预后颈总动脉内中膜厚度(0.80±0.11)nmm,颈动脉膨大处内中膜厚度为(0.91±0.09)mm,颈内动脉内中膜厚度为(0.66±0.05) mm,显著优于对照组[分别为(0.86±0.19)mm、(1.01±0.17) mm、(0.74±0.14) mm],均P＜0.05.结论 缬沙坦联合阿托伐他汀应用在老年单纯收缩期高血压患者中可以有效降低脉压差,改善患者颈动脉内膜厚度,延缓动脉硬化进展.

Valsartan combined with atorvastatin in treatment of elderly patients with isolated systolic hypertension

Objective To investigate the clinical effect and application value ofvalsartan combined with atorvastatin for elderly patients with isolated systolic hypertension.Methods 150 elderly patients with isolated systolic hypertension treated at our hospital were randomly divided into an observation group and a control group,75 cases for each group.The control group were treated with valsartan and the observation group valsartan and atorvastatin.The clinical efficacies of the two groups were recorded.Results After treatment,the systolic blood pressure,diastolic blood pressure,pulse pressure,carotid artery intima-media thickness,carotid artery intimamedia thickness in the enlargement,and internal carotid artery intima-media thickness were (125.28±4.16) mmHg (1 mmHg =0.133 kPa),(72.32±3.28) mmHg,(57.36±2.33) mmHg,(0.80±0.11) mm,(0.91±0.09) mm,and (0.66±0.05) mm in the observation group and were (135.38±8.21) mmHg,(79.66±5.43) mmHg,and (67.76±3.88) mmHg,(0.86±0.19) mm,(1.01±0.17) mm,(0.74±0.14) mm in the control group (P ＜ 0.05).Conclusions Valsartan combined with atorvastatin in treatment of elderly patients with isolated systolic hypertension can effectively decrease pulse pressur,improve the carotid artery intima thickness,and delay the progress of arteriosclerosis.