丹参川芎嗪对老年急性心肌梗死患者炎症因子及血管内皮功能的影响

目的 分析丹参川芎嗪对老年急性心肌梗死患者炎症因子及血管内皮功能的影响.方法 选取本院2012年11月至2016年7月收治的72例老年急性心肌梗死患者,采用随机数字表法分为观察组(n=36)和对照组(n=36),两组均给予常规治疗,观察组加用丹参川芎嗪治疗,治疗2周后评价治疗效果.比较两组炎症因子白细胞介素-6(IL-6)、白细胞计数(WBC)、超敏C反应蛋白(hs-CRP)]、血管内皮功能指标内皮素-1(ET-1)、一氧化氮(N0)、肱动脉介导血流内皮依赖性舒张功能(FMD)]及总有效率.结果 治疗2周后与对照组相比,观察组IL-6、WBC、hs-CRP显著降低,差异均有统计学意义(均P＜ 0.05);与对照组相比,观察组治疗2周后ET-1较低,NO、FMD较高,差异均有统计学意义(均P＜ 0.05);观察组总有效率为91.67％,高于对照组总有效率(66.67％),差异具有统计学意义(x2=6.821,P＜0.05).结论 急性心肌梗死采用丹参川芎嗪治疗,能够缓解机体炎症反应,改善患者血管内皮功能,提高治疗效果,推广价值较高.

Effect of salvia miltiorrhiza and ligustrazine on inflammatory factors and vascular endothelial function in elderly patients with acute myocardial infarction

Objective To investigate the effect of salvia miltiorrhiza and ligustrazine on inflammatory factors and vascular endothelial function in elderly patients with acute myocardial infarction.Methods 72 elderly patients with acute myocardial infarction treated at our hospital from November,2012 to July,2016 were randomly divided into an observation group and a control group,36 cases for each group.The control group were routinely treated and the observation group were treated with salvia miltiorrhiza and ligustrazine.The treatment effect was evaluated after 2 weeks' treatment.The intedeukin-6 (IL-6),white blood cell count (WBC),high sensitivity C-reactive protein (hs-CRP),endothelin-1 (ET-1),nitric oxide (NO),brachial artery-mediated blood flow endothelium-dependent relaxation (FMD),and total effective rate were compared between these two groups.Results After 2 weeks treatment,the levels of IL-6,WBC,hs-CRP,and ET-1 were significantly lower and the level of NO and FMD were higher in the observation group than in the control group (P ＜0.05).The total effective rate was higher in the observation group than in the control group (91.67％ vs.66.67％),with a statistical difference (x 2=6.821,P＜0.05).Conclusions Salvia miltiorrhiza and ligustrazine for acute myocardial infarction can alleviate the body inflammation,improve vascular endothelial function,and improve the therapeutic effect,so it is worth being generalized.