局部给药治疗女性生殖道衣原体阳性患者的疗效及安全性观察

目的 研究单纯宫颈局部给药和全身给药两种治疗方式治疗女性生殖道衣原体(CT)阳性患者的临床效果.方法 选取本院2014年2月至2015年7月收治的78例女性生殖道CT阳性患者,抽签随机分为对照组和观察组,每组39例.其中对照组采用常规疗法口服阿奇霉素片全身给药治疗,观察组采用阿奇霉素注射液宫颈局部给药治疗,7d/疗程,均持续治疗2个疗程.观察两组相关免疫表达因子[防御素5(HD-5)、肿瘤坏死因子α(TNF-α)、白介素8(IL-8)]表达变化,并比较两组疗效及不良反应情况.结果 两组治疗后HD-5、TNF-α、IL-8均有明显下降,差异有统计学意义(P＜0.05),阴道免疫状态均得到较好改善,但两组相较无统计学差异(P＞0.05);观察组治疗有效率87.18％较对照组79.49％无统计学差异(P＞0.05),但观察组不良反应率10.26％较对照组30.77％低,差异有统计学意义(P＜0.05).结论 宫颈局部给药治疗女性生殖道CT阳性具有与全身给药相当的临床疗效,均有改善患者阴道局部的免疫状态;但官颈局部给药具有方便、安全性高等优点,综合效果优于全身给药.

Observation on the effect and safety of local drug delivery in the treatment of female genital chlamydia positive patients

Objective To study the clinical effect of simple cervical local drug delivery and systemic administration in the treatment of female genital chlamydia (CT) positive patients.Methods Seventy-eight female genital CT positive patients admitted in our hospital between February 2014 and July 2015 were randomly divided into control group and observation group,39 cases in each group.Control group was treated with conventional therapy (oral azithromycin tablets systemic drug therapy),while observation group was treated with azithromycin injection cervical local drug delivery.7 days as a course of treatment,both groups were treated for 2 courses.The expression changes of related immune factors [defensin 5 (HD-5),tumor necrosis factor alpha (TNF-α),interleukin 8 (IL-8)] were observed.The curative effect and adverse reactions were compared between two groups.Results After treatment,the levels of HD-5,TNF-α and IL-8 in two groups significantly decreased (P＜0.05),vaginal immune status improved,but there were no statistically significant differences between two groups (P＞0.05).There was no statistically significant difference in the effective rate between observation group and control group (87.18％ vs.79.49％,P＞0.05).The incidence of adverse reactions in observation group (10.26％) was lower than that in control group (30.77％) (P＜0.05).Conclusions The clinical effect of cervical local drug delivery and systemic administration are the same in treating female genital CT positive patients,and both of them can improve the vaginal local immune state.However,cervical local drug delivery has the advantages of convenience and high safety,its comprehensive effect is better than systemic administration.