血糖控制水平对冠心病合并糖尿病患者冠状动脉病变的影响分析

目的 分析血糖控制水平对冠心病合并糖尿病患者冠状动脉病变的影响.方法 选取2013年3月至2015年2月本院收治的冠心病合并2型糖尿病患者100例为研究对象,按照血糖控制水平不同将其分为观察组和对照组,各50例(患者血浆糖化血红蛋白＜6.5％、空腹血糖≤7.0 mmol/L为血糖控制理想).比较两组冠状动脉病变狭窄程度、病变支数及弥漫性病变例数,同时分析两组冠状动脉病变Gensini评分结果,并采用酶联免疫吸附试验(EHSA)检测两组血浆血管性血友病因子(vWF)水平.结果 观察组冠状动脉病变狭窄程度(非重度46.00％,重度34.00％)与对照组(非重度36.00％,重度44.00％)比较,差异无统计学意义(P＞0.05);观察组冠状动脉病变支数(单支4.00％、双支60.00％、3支36.00％)、弥漫性病变(16.00％)显著低于对照组(单支2.00％、双支24.00％、3支74.00％,42.00％),差异具有统计学意义(P＜0.05);观察组HbA1c(2.17±1.20)％]、Gensini评分(49.27±1.14)分]、vWF(65.23±1.24) ％]明显低于对照组,差异具有统计学意义(P＜0.05).结论 糖尿病可加重冠状动脉病变程度,因此可通过控制血糖水平、降低vWF来减少冠心病冠脉病变.

Effect of blood glucose control level on coronary artery lesions in patients with coronary heart disease complicated with diabetes

Objective To analyze the effect of blood glucose control level on coronary artery lesions in patients with coronary heart disease complicated with diabetes.Methods One hundred patients with coronary heart disease complicated with type 2 diabetes mellitus treated at our hospital from March,2013 to February,2015 were selected as study objects and were divided into an observation group and a control group according to different blood glucose control levels (plasma glycosylated hemoglobin ＜ 6.5％ and fasting blood glucose ≤ 7.0 mmol/L indicate ideal blood glucose control),50 cases for each group.The degree of coronary artery stenosis,the number of affected vessels,and the number of cases with diffuse lesions were compared between these two groups.The Gensini scores of coronary artery disease in the two groups were analyzed.The levels of von Willebrand factor (vWF) were compared between these two groups by enzyme linked immunosorbent assay (ELISA).Results There were no statistical differences in the degrees of coronary artery stenosis between the observation group (non-severe 46.00％,severe 34.00％) and the control group (non-severe 36.00％,severe 44.00％) (P ＞ 0.05).The numbers of affected vessels (single 4.00％,double vessels 60.00％,three vessels 36.00％) and diffuse lesions (16.00％) in the observation group were significantly lower than those in the control group (single 2.00％,double vessels 24.00％,three vessels 74.00％,diffuse lesions 42.00％) (P ＜ 0.05);HbAlc (2.17±1.20)％],Gensini score (49.27±1.14)] and vWF (65.23±1.24)％] in the observation group were significantly lower than those in control group (P ＜ 0.05).Conclusion Diabetes aggravates the degree of coronary artery lesions.Therefore,coronary artery lesions can be reduced by controlling blood glucose levels and reducing vWF.