他克莫司软膏治疗光敏性皮肤病的临床观察

目的 研究并探讨他克莫司软膏治疗光敏性皮肤病的临床疗效.方法 选取2014年1月至2016年6月期间本院收治的90例光敏性皮肤病患者作为研究对象,采取计算机数字随机序列法将患者分为两组,每组45例.对照组患者采用喜辽妥软膏外涂,观察组患者采用他克莫司软膏外涂,比较两组患者的临床总有效率、皮肤瘙痒评分、皮损评分、生活质量评分、不良反应发生情况.结果 观察组患者治疗2周后、治疗4周后的临床总有效率分别为82.22％、95.56％,对照组分别为60.00％、80.00％,两组比较差异均有统计学意义(均P＜ 0.05).治疗4周后,两组患者的皮肤瘙痒评分、皮损评分、生活质量评分均较治疗前明显降低(P＜0.05);观察组患者治疗4周后的皮肤瘙痒评分、皮损评分、生活质量评分较对照组更低(P＜0.05).在治疗过程中,观察组患者的不良反应发生率为8.89％,对照组为6.67％,两组比较差异无统计学意义(P＞0.05).结论 采用他克莫司软膏外涂治疗光敏性皮肤病具有显著的临床疗效,可有效缓解患者的皮肤瘙痒、皮损等症状,改善患者的生活质量,且不良反应较少.

Clinical observation of tacrolimus ointment in the treatment of photosensitive skin diseases

Objective To investigate the clinical efficacy of tacrolimus ointment in the treatment of photosensitive skin diseases.Methods 90 cases of photosensitive skin diseases in our hospital from January 2014 to June 2016 were selected as the research object,and divided into two groups randomly,45 cases in each group.The control group was treated with hirudoid ointment,while the observation group was treated with tacrolimus ointment.The clinical total efficiency,pruritus score,lesion score,life quality score,and the occurrence of adverse reactions were compared between two groups.Results The total effective rate in the observation group after 2 weeks and 4 weeks of treatment were 82.22％ and 95.56％ respectively,those in the control group were 60.00％ and 80.00％,with statistically significant differences between the two groups (P＜0.05).After 4 weeks of treatment,the skin pruritus score,lesion score,and life quality score in the two groups were significantly lower than those before treatment (P＜0.05);the skin pruritus score,lesion score,and life quality score in the observation group were lower than those in the control group (P＜0.05).In the course of treatment,the incidence of adverse reactions in the observation group was 8.89％,and 6.67％ in the control group,without statistically significant difference between the two groups (P＞0.05).Conclusion Tacrolimus ointment in the treatment of photosensitive skin diseases has significant clinical efficacy,can effectively relieve skin itching,skin lesions,and other symptoms in patients,improve the quality of life of patients,with fewer adverse reactions.