硫酸镁联合硫酸沙丁胺醇对重度支气管哮喘急性发作患儿肺功能的影响

目的 探讨硫酸镁联合硫酸沙丁胺醇对重度支气管哮喘急性发作患儿肺功能的影响.方法 选择本院2015年1月至2016年6月期间收治的60例重度支气管哮喘急性发作患儿作为观察对象,随机分为观察组和对照组,每组30例.对照组采用硫酸沙丁胺醇治疗,观察组予以硫酸镁联合硫酸沙丁胺醇治疗,治疗1周后比较两组治疗效果、康复指标(哮鸣音、气短、咳嗽)、住院时间、肺功能指标最大呼气流量(PEF)、1秒用力呼气容积(FEV1)、用力肺活量(FVC)]与不良反应.结果 观察组总有效率为96.67％,显著高于对照组的70.00％,差异有统计学意义(x 2=7.680,P＜0.05);治疗后与对照组相比,观察组哮鸣音消失时间(1.04±0.35)d]、气短消失时间(2.11±1.25)d]、咳嗽消失时间(3.75±1.08)d]及住院时间(5.28±1.53)d]均较短,差异均有统计学意义(均P＜0.05);两组治疗前的肺功能指标比较差异均无统计学意义(均P＞ 0.05);治疗后两组FEV1、PEF、FVC水平均显著升高,且观察组上升趋势更为显著,差异均有统计学意义(均P＜ 0.05);两组患儿不良反应发生率比较差异无统计学意义(x 2=0.267,P＞0.05).结论 与单纯采用硫酸沙丁胺醇治疗重度支气管哮喘急性发作相比,硫酸镁联合硫酸沙丁胺醇治疗效果更加确切,且不良反应较少,对改善患儿临床症状与肺功能均具有积极作用,值得临床进一步推广应用.

Effect of magnesium sulfate combined with salbutamol sulfate on lung function in children with acute attack of severe bronchial asthma

Objective To investigate the effect of magnesium sulfate combined with salbutamol sulfate on lung function in children with acute attack of severe bronchial asthma.Methods 60 children with acute attack of severe bronchial asthma admitted into our hospital from January 2015 to June 2016 were randomly divided into observation group and control group,30 cases in each group.Control group took salbutamol sulfate,and observation group took magnesium sulfate combined with salbutamol sulfate.After treatment for 1 week,the curative effect,recovery indexes (wheeze,short of breath,cough),hospital stay,lung function indexes peak expiratory flow (PEF),forced expiratory volume in one second (FEV1),forced vital capacity (FVC)],and adverse reactions of two groups were compared.Results The total effective rate of observation group was 96.67％,which was significantly higher than 70.00％ of control group (x 2=7.680,P＜0.05).After treatment,compared with control group,the disappearance time of wheeze,short of breath,cough,and hospital stay (1.04±0.35)d,(2.11±1.25)d,(3.75±1.08)d,(5.28±1.53)d] in observation group were shorter (P＜0.05).Before treatment,there were no statistically significant differences in the lung function indexes between the two groups (P＞0.05);after treatment,the levels of FEV1,PEF,FVC in two groups significantly increased,and the increased tendency of observation group was more significant (P＜0.05).There was no statistically significant difference in the incidence of adverse reactions between the two groups (x 2=0.267,P＞0.05).Conclusion Compared with pure use of salbutamol sulfate for treating acute attack of severe bronchial asthma,magnesium sulfate combined with salbutamol sulfate has more definite curative effect and less adverse reactions,which can improve clinical symptoms and lung function,worthy of further clinical application.