复方甘草酸苷对巨细胞病毒肝炎患儿肝损害的保护作用研究

目的 探讨复方甘草酸苷对巨细胞病毒肝炎(CMV)患儿肝损害的保护作用.方法 选取2014年1月至2016年5月本院儿科收治的72例确诊为CMV的患儿作为研究对象,随机将其分为对照组和观察组,每组36例,对照组患儿予以护肝、抗病毒及退黄疸等CMV肝炎对症治疗,观察组在对照组基础上予以加用复方甘草酸苷注射治疗,比较两组患儿肝功能相关指标水平、影像学检查结果和临床疗效及治疗过程中不良反应的发生情况.结果 2组患儿治疗后ALT、AST、TBIL、DBIL、IBIL及TBA均较治疗前明显下降,且观察组下降程度均明显大于对照组(P＜0.05).观察组临床总有效率明显高于对照组(94.44％比72.22％),差异有统计学意义(P＜0.05).对照组不良反应发生14例(38.89％)明显高于观察组的5例(13.89％),两组比较差异有统计学意义(P＜ 0.05).结论 复方甘草酸苷可短期降低CMV肝炎患儿的ALT、AST、TBIL、DBIL、IBIL及TBA水平,临床疗效良好,对CMV肝炎患儿其肝损害具有一定保护作用.

The protective effect of compound glycyrrhizin on liver damage in children with cytomegalovirus hepatitis

Objective To investigate the protective effect of compound glycyrrhizin on liver damage in children with cytomegalovirus hepatitis (CMV).Methods 72 children with CMV in department of paediatrics of our hospital from January 2014 to May 2016 were randomly divided into two groups,36 patients in each group.The control group was given liver protection,antivirus,treating jaundice,and other symptomatic treatment,and the observation group was treated with compound glycyrrhizin injection on the basis of the control group.Compared the liver function,radiological data,curative effect,and adverse reactions between the two groups.Results After treatment,the levels of ALT,AST,TBIL,DBIL,IBIL,and TBA in the two groups significantly decreased compared with before treatment,and those in the observation group were significantly lower than those in the control group (P＜0.05).The total effective rate of the observation group was 94.44％,significantly higher than 72.22％ of the control group (P＜0.05).14 patients (38.89％) in the control group had adverse reactions,and 5 patients (13.89％) in the observation group had adverse reactions,with statistically significant difference (P＜0.05).Conclusion Compound glycyrrhizin can reduce the levels ofALT,AST,TBIL,DBIL,IBIL,and TBA and relieve liver damage,has clinical curative effect on children with cytomegalovirus hepatitis.