The Molecular Mechanism of B Cell Activation by toll-like Receptor Protein RP-105 |
| |
Authors: | Vivien W.F. Chan, Ingrid Mecklenbr uker, I-hsin Su, Gemma Texido, Michael Leitges, Rita Carsetti, Clifford A. Lowell, Klaus Rajewsky, Kensuke Miyake, Alexander Tarakhovsky |
| |
Affiliation: | Vivien W.F. Chan, Ingrid Mecklenbräuker, I-hsin Su, Gemma Texido, Michael Leitges, Rita Carsetti, Clifford A. Lowell, Klaus Rajewsky, Kensuke Miyake, and Alexander Tarakhovsky |
| |
Abstract: | The B cell–specific transmembrane protein RP-105 belongs to the family of Drosophila toll-like proteins which are likely to trigger innate immune responses in mice and man. Here we demonstrate that the Src-family protein tyrosine kinase Lyn, protein kinase C β I/II (PKCβI/II), and Erk2-specific mitogen-activated protein (MAP) kinase kinase (MEK) are essential and probably functionally connected elements of the RP-105–mediated signaling cascade in B cells. We also find that negative regulation of RP-105–mediated activation of MAP kinases by membrane immunoglobulin may account for the phenomenon of antigen receptor–mediated arrest of RP-105–mediated B cell proliferation. |
| |
Keywords: | RP-105 B lymphocytes signal transduction mice |
|
|