缺血性脑卒中患者阿司匹林抵抗现象及处理策略

阿司匹林作为缺血性脑血管病的一级和二级预防用药，广受关注。然而长期服用阿司匹林的患者仍会发生动脉血栓形成事件，因此本文就阿司匹林抵抗的概念、发生机制、检测方法、预防措施及其在缺血性脑血管病中的临床意义加以综述。

The treatment of aspirin resistance in patients with cerebral arterial thrombosis

Aspirin is an effective antiplatelet agent with proven benefit in the first and second prevention of cerebral vascular disease. The antithrombotic effects of aspirin, however, are variable among individuals and this might explain, in part, why vascular events occur even in patients receiving aspirin therapy. Although formal diagnostic criteria are lacking, aspirin resistance generally describes the failure of aspirin to produce an expected biological response or the failure of aspirin to prevent atherothrombotic events. Aspirin resistance has been reported to occur in 5.5% to 60% of the general population, therefore, its detection is potentially of clinical importance. The concept, biological mechanisms, laboratory methods for detection, preventive methods and clinical relevance of aspirin resistance are discussed in this review.