类固醇激素治疗急性颈髓损伤的临床观察

目的：观察甲基强地松龙、地塞米松对急性颈髓损伤的疗效，探讨激素治疗脊髓损伤的作用及机理。方法：对59例颈髓损伤手术后的患者进行回顾性研究，按治疗方法分为甲基强地松龙组（19例）、地塞米松组（25例）和常规组（15例），根据脊髓损伤的神经功能评分标准，评定脊髓损伤程度并比较疗效，记录临床表现及并发症。结果：3组患者治疗后感觉及运动功能均有显著改善（P＜0．05），甲基强地松龙组感觉改善优于另外两组，运动改善优于地塞米松组。地塞米松组与常规组疗效无显著性差异。3组并发症发生率无明显差异。结论：类固醇激素可改善急性脊髓损伤患者的运动及感觉功能，甲基强地松龙的作用优于地塞米松。

A clinical study of steroid hormone on the treatment in acute cervical spinal cord injury

Objective:To observe the theraputic effect of methylprednisolone and dexamethasone on acute cervical spinal cord injury,and to explore the function and mechanism of steroid.Method:59 patients with cervical spinal cord injury and post operation were divided into methylprednisolone group(19 cases), dexamethasone group(25 cases) and routine treatment group(15 cases).Based on the neural and functional grade standard of spinal cord injury,the degree of damage were assessed and the clinical data and complications were recorded.Result:The function of sensory and motor in the three groups were all improved remarkably( P <0 05).The sensory improvement of the methylprednisolone group was better than the other two groups and the motor improvement of the methylprednisolone group was better than routine treatment group.There was no different in the treatment effect between the dexamethasone group and routine treatment group.There was no different in the complications among the three groups.Conclusion:The steroid hormone can improve the function of sensory and motor function in patients with acute spinal cord injury.The theraputic effect of the methylprednisolone was better than that of the dexamethasone.