慢性肾上腺皮质功能减退症70例临床分析

目的：复习原发性和继发性慢性肾上腺皮质功能减退症的病因和临床特点。方法：回顾性分析70例慢性肾上腺皮质功能减退症的临床资料。结果及结论：原发性和继发性的慢性肾上腺皮质功能减退症病因分别以结核及席汉综合征为多。两者共有表现为食欲减退、疲乏无力、体重减轻、低血压、贫血、低钠血症、低血糖和血皮质醇、尿皮质醇降低。原发性者以色素沉着和血浆促肾上腺皮质激素（ACTH）值升高为特点，可见高钾血症；继发性者则表现肤色浅淡，常有多种垂体激素缺乏表现，ACTH降低或正态，无高钾血症。

Clinical analysis of 70 cases with chronic adrenocortical hypofunction.

Objective:To investigate the etiology and clinical characteristics of primary(Addison's disease)and secondary a-drenocortical hypofunction.Method:The clinical data of70cases with chronic adrenocortical hypofunction were reviewed.Results and Conclusions:The main cause of Addison's disease was tuberculosis while in secondary adrenocrotical hypofunction was postpar-tum haemorrhage.The common features were anorexia,fatigue,weakness,weight loss,hypotension,anemia,hyponatremia,hypo-glycemia,and decreasing of cortisol levels in plasma and urine.Addison's disease was characterized by Hyperpigmentation,increased serum adrenocorticotrophin(ACTH)and hyperkalemia.In secondary adrenocortical hypofunction,the clinical characteristics were hypopig mentation,the manifestation of multiple pituitary hormones hypofunction,decreased or normal serum ACTH level but absence of hyperkalemia.