血清肝纤维化与肝功能及肝肿瘤指标的关系

目的探讨血清透明质酸(HA)、层黏蛋白(LN)、IV型胶原(IVC)在慢性肝病血清中的变化,并分析肝纤维化与肝功能和肝肿瘤指标之间的关系。方法以放射免疫法检测69例慢性乙型肝炎、48例乙肝肝硬化及36例原发性肝癌患者血清HA,LN,IVC水平,同时常规检测肝功能指标白蛋白(ALB)、总胆红素(TBIL)、AST、ALT及γGT和血清甲胎蛋白(AFP)水平,并设30例健康对照。结果原发性肝癌和乙肝肝硬化组血清HA、LN及IVC水平较健康对照组均有明显的升高(P<0.01),且以HA最具意义。血清HA、LN及IVC与TBIL、AST、ALT及γGT均呈正相关,与ALB呈负相关;3项肝纤维化指标与AFP无相关性。结论血清HA、LN及IVC联合检测在肝纤维化及早期肝硬化诊断中具有较高的临床价值;血清肝纤维化指标与肝功能指标相关,而与AFP无相关性。

Relationship between Hepatic Fibrosis and Hepatic Function or Hepatic Carcinoma Index

Objective To investigate the change of HA,LN,IVC in the serum of chronic liver diseases and the relationship between the hepatic fibrosis and hepatic function or hepatic carcinoma index. Methods Radioimmunoassay was used to detect the serum level of HA,LN,IVC in patients with chronic hepatitis B (69 cases),hepatitis B cirrhosis (48 cases),primary hepatic carcinoma (36 cases) and healthy control(30 cases) ,while hepatic function index including ALB,TBIL,AST,ALT,γGT and hepatic carcinoma index(AFP) were detected. Results The serum levels of HA,LN,IVC in the patients with primary carcinoma of liver or hepatocirrhosis increased obviously compared with those in the healthy subjects and HA was highlight. HA,LN,IVC showed an obvious positive correlation to TBIL,AST,ALT andγGT,while negative correlation with ALB,whereas no significient relationship was found between fibrosis index and AFP. Conclusion Joint detection of serum HA,LN,IVC is of higher significance in clinical diagnosis.There was correlation between the serum fibrosis index and function index,but without significant relation between the serum fibrosis index and AFP.