Cavitary pulmonary involvement of diffuse large B-cell lymphoma transformed from extra nodal marginal zone B-cell lymphoma MALT type |
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Authors: | Hiromichi Yamane Masahiro Ohsawa Yasuhiro Shiote Shigeki Umemura Toshimitsu Suwaki Atsuko Shirakawa Haruhito Kamei Nagio Takigawa Katsuyuki Kiura |
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Affiliation: | (1) Division of Clinical Oncology, Sumitomo-Besshi Hospital Cancer Center, 3-1 Oji-cho, Niihama Ehime, 792-8543, Japan;(2) 4th Department of General Medicine, Kawasaki Medical School, 2-1-80 Nakasange, Okayama 700-8505, Japan;(3) Department of Respiratory Medicine, Okayama University Hospital, 2-5-1 Shikata-cho, Okayama 700-8558, Japan;(4) Division of Pathology, Sumitomo-Besshi Hospital Cancer Center, 3-1 Oji-cho, Niihama Ehime, 792-8543, Japan |
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Abstract: | We describe a case of pulmonary diffuse large B-cell lymphoma (DLBCL), which was thought to arise from extranodal marginal zone lymphoma of mucosa-associated lymphoid tissue (MALT lymphoma). A 68-year-old woman presented with a 2-month history of cough and bloody sputum. The chest X-ray and computed tomography revealed a mass with cavitation in the right lower lobe. Transbronchial biopsy specimens revealed a granulomatous infiltration without malignant cells. However, diagnosis of MALT lymphoma was established from gastric biopsy specimen. Subsequently, a right lower lobectomy was performed because of hemoptysis. Examination of the resected specimen revealed a diffuse large B-cell lymphoma, which was considered to have transformed from MALT lymphoma, because both lung and stomach lesions had the chromosomal translocation t(11;18)(q21;q21) in common. In addition, there were no nodules, masses, alveolar or interstitial infiltrates in the lung fields, which are usually observed in the case of marginal zone B-cell lymphoma of bronchial mucosa-associated lymphoid tissue. These findings indicate that involvement of DLBCL have to be considered in patients with MALT lymphoma and cavitary lesion of the lung. |
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