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| 奥特拉西的合成及光谱测定 | |
| 引用本文： | 王浦海,朱清岭,戚苏民,严相平,梅毓华.奥特拉西的合成及光谱测定[J].药学与临床研究,2008,16(2):108-110. |
| 作者姓名： | 王浦海 朱清岭 戚苏民 严相平 梅毓华 |
| 作者单位： | 1. 南京工业大学江苏省药物研究所,南京,210009 2. 扬子江药业集团有限公司,泰州,225321 3. 南京大学化学化工学院,南京,210008 |
| 摘 要： | 目的:合成奥特拉西并改进合成工艺.方法:以尿囊素为原料,在碱性条件下以溴素为氧化剂,一步反应制得奥特拉西.结果和结论:所得产物经元素分析、紫外光谱、红外光谱、核磁共振谱及质谱等确证结构,说明此合成方法是可行的. |
| 关 键 词： | 抗肿瘤药 奥特拉西 合成 尿囊素 |
| 收稿时间： | 2007/12/6 0:00:00 |
Synthesis and characterization of oteracil |
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| WANG Pu-hai,ZHU Qing-ling,QI Su-min,YAN Xiang-ping and MEI Yu-hua.Synthesis and characterization of oteracil[J].Pharmacertical and Clinical Research,2008,16(2):108-110. | |
| Authors: | WANG Pu-hai ZHU Qing-ling QI Su-min YAN Xiang-ping and MEI Yu-hua |
| Institution: | Jiangsu Institute of Materia Medica, Nanjing University of Technology, Nanjing, 210009, China;Yangtze River Pharmacy Group, Taizhou, 225321, China;Yangtze River Pharmacy Group, Taizhou, 225321, China;Jiangsu Institute of Materia Medica, Nanjing University of Technology, Nanjing, 210009, China;School of Chemistry & Chemical Engineering, Nanjing University, Nanjing, 210008, China |
| Abstract: | Objective:To synthesize oteracil and optimize the synthetic process. Method:Oteracil was synthesized from allantoin by oxidation. Result and Conclusion:Chemical structure of oteracil was conformed by element analysis, UV, IR, NMR and ESI-MS etc. The proposed synthetic method was feasible. |
| Keywords: | Antitumor drug Oteracil Synthesis Allantoin |
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