| P75神经营养受体与视网膜细胞凋亡 |
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| 引用本文： | 贡亦清,陈逖.P75神经营养受体与视网膜细胞凋亡[J].国际眼科杂志,2005,5(4):742-744. |
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| 作者姓名： | 贡亦清 陈逖 |
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| 作者单位： | 1. 212000,中国江苏省镇江市第一人民医院眼科
2. 230000,中国安徽省合肥市,安徽医科大学第一附属医院眼科 |
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| 摘 要： | P75神经营养受体是最早发现的神经营养因子受体，既往认为其主要作为高亲和力受体的辅助受体间接发挥作用。近年来研究表明，P75神经营养受体在神经系统的发育中有诱导细胞凋亡作用。现阐述其在视网膜神经细胞生长，分化以及逆向运输神经营养因子等方面的作用。
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| 关 键 词： | P75神经营养受体 视网膜细胞 细胞凋亡 神经营养因子 信号传递 |
| 收稿时间： | 03 21 2005 12:00AM |
| 修稿时间： | 06 27 2005 12:00AM |
Neurotrophin receptor P75 and retinal cell apoptosis |
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| Yi-Qing Gong,Ti Cheng.Neurotrophin receptor P75 and retinal cell apoptosis[J].International Journal of Ophthalmology,2005,5(4):742-744. |
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| Authors: | Yi-Qing Gong Ti Cheng |
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| Institution: | Yi-Qing Gong1,Ti Cheng2 1 Department of Ophthalmology,the First People's Hospital of Zhenjiang City,Zhenjiang 212000,Jiangsu Province,China, 2 Department of Ophthalmology,the First Affiliated Hospital of Anhui Medical University,Hefei 230000,Anhui Province,China |
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| Abstract: | Neurotrophin receptor P75, the first member to be identified in the family of neurotrophin receptors, was initially described as the accessory receptor of tropomyosin receptor. Recent evidence indicates that it is involved in regulating programmed cell death during development, we studied its role in neurogenesis, differentiation and retrograde transport of neurotrophins in nerve layer of retina in this article. |
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| Keywords: | neurotrophin receptor apoptosis retina |
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