| 内皮抑素联合TACE治疗原发性肝癌的应用前景 |
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| 引用本文： | 孙新刚,沈晓文.内皮抑素联合TACE治疗原发性肝癌的应用前景[J].当代医学,2010,16(29):554-555. |
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| 作者姓名： | 孙新刚 沈晓文 |
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| 作者单位： | 江苏,214002,南京医科大学附属无锡二院介入放射科;江苏,214002,南京医科大学附属无锡二院介入放射科 |
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| 摘 要： | 原发性肝癌TACE后残存癌细胞血管内皮生长因子的表达能刺激新生血管的生长,有助于残存癌细胞的存活,并可能在TACE术后残癌组织血供重建中起重要的作用;内皮抑素可以特异性作用于新生血管的内皮细胞,抑制内皮细胞的迁移、诱导其凋亡而抑制肿瘤新生血管形成和肿瘤生长;内皮抑素联合TACE治疗原发性肝癌将有一个良好的临床应用前景。
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| 关 键 词： | 肿瘤 血管内皮生长因子 内皮抑素 肝肿瘤/治疗 肝动脉化学栓塞 |
Endostatin Combined with TACE in the Treatment of Primary hepatocellular carcinoma |
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| SUN Xin-gang,SHEN Xiao-wen.Endostatin Combined with TACE in the Treatment of Primary hepatocellular carcinoma[J].Contemporary Medicine,2010,16(29):554-555. |
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| Authors: | SUN Xin-gang SHEN Xiao-wen |
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| Institution: | SUN Xin-gang,SHEN Xiao-wen.Department of Interventional Radiology,Wu Xi Second Hospital Affiliated Hospital,Nan Jing Meddical University,Wu Xi 214002,China |
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| Abstract: | After TACE treatment of primary hepatocellular carcinoma,VEGF secreted by the residual tumor cells may stimulate angiogenesis,resulting in rebuilding of tumor blood supply and helping the tumor cells survive;Endostatin can specifically target endothelial cells,inhibiting migration and indapoptosis,thereby inhibiting angiogenesis and tumor growth;The treatment of primary hepatocellular carcinoma that Endostatin combined with TACE would be a favorable clinical perspective. |
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| Keywords: | Tumor Vascular endothelial growth factor Endostatin Liver tumor/treatment Transcatheterhepatic arterial chemoembotization |
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