| 参莲方对大鼠动脉粥样硬化病变形成过程影响的动态观察 |
| |
| 引用本文： | 陈丽娜,李玉洁,杨庆,翁小刚,周立运,朱晓新. 参莲方对大鼠动脉粥样硬化病变形成过程影响的动态观察[J]. 中国中药杂志, 2011, 36(1): 66-71 |
| |
| 作者姓名： | 陈丽娜 李玉洁 杨庆 翁小刚 周立运 朱晓新 |
| |
| 作者单位： | 1. 国家中医药管理局,科技司,北京,100027
2. 中国中医科学院,中药研究所,北京100700 |
| |
| 基金项目： | 国家自然科学基金面上项目(30973901);国家直属科研院所技术开发研究专项资金(NCSTE-2007-JKZX-301);重大新药创制综合性中药新药研究开发技术大平台项目(2009 ZX093 01-005-2-4);中国中医科学院自主选题项目(ZZ20090207) |
| |
| 摘 要： | 目的:建立大鼠动脉粥样硬化(AS)模型,观察动脉粥样硬化早期病变的动态变化过程和参莲方的干预作用.方法:240只大鼠随机分为空白对照组、模型组、阳性药组(阿司匹林0.027 g·kg-1)、参莲方高、中、低剂量组(0.675,1.35,2.70 g·kg-1).采用球囊损伤法+半量高脂饲料建立AS模型,并给予参莲方治疗.HE法观察血管病理学变化,采用酶比色法、清除法、硝酸还原酶法测定TC,TG,LDL-C,HDL-C,NO水平的变化,放免法观察ET,TXB2,6-keto-PGF1α,TNF-α,IL-6及IL-8水平的变化.结果:参莲方各剂量组和同阶段模型组相比血管损伤均有明显改善,内膜炎细胞浸润、中膜增厚和平滑肌增殖减轻,第8周末参莲方组无明显脂质条纹出现.参莲方各剂量组血清TC,NO,TXB2的含量明显降低(P<0.05);高剂量组可明显降低血清TNF-α,IL-6,IL-8水平(P<0.05).结论:参莲方能够通过调节血脂,改善血管内皮功能,减少血液循环中炎症介质的释放,抑制AS病变的形成和发展.
|
| 关 键 词： | 参莲方 动脉粥样硬化 炎症 |
| 收稿时间： | 2010-03-15 |
Influence of Shenlian decoction on early lesion of atherosclerosis in rats |
| |
| CHEN Li''n,LI Yujie,YANG Qing,WENG Xiaogang,ZHOU Liyun and ZHU Xiaoxin. Influence of Shenlian decoction on early lesion of atherosclerosis in rats[J]. China Journal of Chinese Materia Medica, 2011, 36(1): 66-71 |
| |
| Authors: | CHEN Li''n LI Yujie YANG Qing WENG Xiaogang ZHOU Liyun ZHU Xiaoxin |
| |
| Affiliation: | Technology Department, State Administration of Traditional Chinese Medicine, Beijing 100027, China;Institute of Chinese Materia Medica, China Academy of Chinese Medical Sciences, Beijing 100700, China;Institute of Chinese Materia Medica, China Academy of Chinese Medical Sciences, Beijing 100700, China;Institute of Chinese Materia Medica, China Academy of Chinese Medical Sciences, Beijing 100700, China;Institute of Chinese Materia Medica, China Academy of Chinese Medical Sciences, Beijing 100700, China;Institute of Chinese Materia Medica, China Academy of Chinese Medical Sciences, Beijing 100700, China |
| |
| Abstract: | Objective: To establish the atherosclerosis models(AS) in rats and observe the change process of AS and Shenlian decoction's pharmacological effect.Method: Two hundreds and forty rats were randomly divided into blank control group,model group,positive medicine group,the high-dose,middle dose and low-dose Shenlian decoction groups.Vascular pathological changes were observed by the methods of HE stain.The levels of TC,TG,LDL-C,HDL-C,NO in serum were determined respectively by enzyme colorimetric,clear and nit... |
| |
| Keywords: | Shenlian decoction atherosclerosis inflammation |
| 本文献已被 CNKI 万方数据 等数据库收录！ |
|
