高血压病患者胰岛素与血脂协同关系的研究

目的探讨高血压病患者胰岛素水平变化与血脂的协同关系。方法选取单纯高血压病患者（高血压组）、高血压伴代谢综合征患者（高血压伴代谢综合征组）和健康体检者（对照组）各40例，测血压及血清胆固醇（TC）、甘油三酯（TG）和空腹胰岛素。用单因素方差分析判定各组间参数差异的统计学意义，用多因素方差分析血脂、胰岛素与高血压的相互影响情况。结果高血压组TC（6．27±1．24）mmol／L、TG（2．34±1．25）mmol／L，高血压伴代谢综合征组TC（6．28-I-1．36）mmol／L、TG（2．69±1．32）mmol／L，2组与对照组TC（5．49±1．06）mmol／L与TG（1．17±0．50）mmol／L比较，差异均有统计学意义（均P〈0．01）；3组空腹胰岛索分别为（16．42±5．38）、（21．47±5．73）和（28．05±7．32）mU／L，高血压伴代谢综合征组与对照组比较，差异有统计学意义（P〈0．01）；多因素方差分析结果显示，单纯的血脂及单纯的胰岛素水平增高与高血压无明显相关（P〉0．05），仅在血脂和胰岛素两者都增高时，与高血压有明显相关（P〈0．01）。结论血脂、胰岛素两者都增高时与高血压之间存在着明显的协同关系。

Study of synergic relationship between insulin and blood-lipid in hypertension

Objective To investigate the relationship between insulin change and blood-lipid in hypertension.Methods Forty lone hypertensive,40 hypertension concomitant with metabolic syndrome and 40 healthy persons(control group)were enrolled in this study.Blood pressure was measured.Blood samples were drawn in an empty stomach,and both insulin and lipid were determined between 8am and 9 am.Mutual effects among blood-lipid,insulin and hypertension were analyzed with multi-way ANOVA.Results Lone hypertension group showed that TC was 6.27±1.24 and TG was 2.34±1.25.Hypertensive concomittant with metabolic syndrome group showed thal TC was 6.28±1.36 and TG was 2.69±1.32 respectively.Compare with control group,both groups showed statistical significance(P＜0.01).FINS of the three groups were 16.42±5.38,21.47±5.73 and 28.05±7.32 respectivly,showing no significant difference(P＞0.05).Multifaetor ANOVA showed no very seriously effects on hypertension if either blood-lipid increase or insulin increased,but side effects occurred if blood.1ipid increase with insulin(P＜0.01).Conclusion There is insulin resistance and disturbance of lipid metabolism in hypertensive,and there is also correlation among simplex blood-lipid,insulin change and hypertensive compound with metabolic syndrome.