| 克拉霉素纳米乳的制备及体外释放度研究 |
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| 引用本文： | 汤祎,吕竹芬,陈燕忠,谢清春,申楼.克拉霉素纳米乳的制备及体外释放度研究[J].广东药学院学报,2006,22(6):579-582. |
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| 作者姓名： | 汤祎 吕竹芬 陈燕忠 谢清春 申楼 |
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| 作者单位： | 广东省药物新剂型重点实验室/广东药学院药物研究所,广东,广州,510006 |
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| 基金项目： | 广东省广州市科技攻关项目 |
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| 摘 要： | 目的 制备克拉霉素(CLM)纳米乳,并对药物释放机制进行初步研究.方法 以乙基纤维素(EC)为阻滞材料,将CLM制成缓释纳米乳,考察EC的种类及用量、油水相比例、乳化剂用量和制备工艺等对其体外释放度的影响.结果 CLM纳米乳的体外释药符合Higuchi规律,释药速率主要受EC的种类及用量、乳化剂用量和制备工艺等因素的影响.结论 CLM纳米乳体外释药符合缓释制剂要求.
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| 关 键 词： | 克拉霉素 纳米乳 乙基纤维素 释放度 |
| 文章编号： | 1006-8783(2006)05-0579-04 |
| 收稿时间： | 2006-09-30 |
| 修稿时间： | 2006-11-17 |
Preparation and in vitro dissolution of clarithromycin nanoemulsion |
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| TANG Yi,LU Zhu-fen,CHEN Yan-zhong,XIE Qing-chun,SHEN Lou.Preparation and in vitro dissolution of clarithromycin nanoemulsion[J].Academic Journal of Guangdong College of Pharmacy,2006,22(6):579-582. |
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| Authors: | TANG Yi LU Zhu-fen CHEN Yan-zhong XIE Qing-chun SHEN Lou |
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| Abstract: | Objective To optimize the preparation procedure of water-in-oil nanoemulsion of clarithromycin and investigate its in vitro dissolution behavior.Methods Clarithromycin nanoemulsion was prepared by mixing clarithromycin with the ethylcellulose.Factors related to clarithromycin in vitro release characteristics were evaluated,which included type and quantity of ethylcellulose and emulsifier,ratio of water to oil.Results The type and quantity of ethylcellulose,the amount of emulsifier,preparation method were closely related to the in vitro dissolution of clarithromycin.The dissolution data of the nanoemulsion were best described by Higuchi model.Conclusion The profile of clarithromycin nanoemulsion indicates that the nanoemulsion is an ideal sustained-release formulation. |
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| Keywords: | clarithromycin nanoemulsion ethylcellulose in vitro dissolution |
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