弱激光照射对正畸移动牙牙周组织骨形成蛋白表达的研究

目的:本实验研究弱激光照射对实验性正畸牙齿移动中骨形成蛋白表达的变化,探讨弱激光局部照射对正畸牙齿移动时骨改建的影响。方法:在兔实验性正畸牙齿移动过程中,局部照射弱激光,经免疫组化染色、运用计算机图像分析,对兔牙周组织中骨形成蛋白的表达变化进行定量分析。结果:弱激光照射侧压力区和张力区骨形成蛋白表达增强现象较非照射侧出现的早,峰值高,而且持续的时间长。结论:正畸牙齿移动时局部照射弱激光增强了骨形成蛋白的表达,提示弱激光照射有促进骨改建,加速正畸牙齿移动的趋势。

Effect of Low-power Laser Irradiation on the Expression of Bone Morphogenetic Protein in the Experimental Orthodontic Tooth Movement

Objective:The present study investigated the expression level of bone morphogenetic proteins (BMP) during the movement of experimental orthodontic teeth irradiated with low_power laser, in order to explore the effect of local irradiation with low_power laser on the bone remodeling during orthodontic tooth movement.Methods: Rabbits were given local irradiation with low_power laser during the movement of their teeth induced with the experimental orthodontic appliance. BMP in periodontal tissue of the orthodontic teeth was examined quantitatively using immunohistochemical stain and image analysis system.Results: The expression level of BMP increased in a higher level in the early stage and lasted for a long time in the compression and tension area on the side irradiated with low_power laser than on the side without laser irradiation.Conclusion: During the movement of orthodontic teeth, local irradiation with low_power could increase the expression of BMP. It suggests that the irradiation with low_power laser could promote bone remodeling and accelerate the movement of orthodontic teeth.