| 高效液相色谱法测定稳心胶囊三七中人参皂苷Rb1含量 |
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| 引用本文： | 楼晓峰,胡献跃,方肖庆,郑望升,黄秀清. 高效液相色谱法测定稳心胶囊三七中人参皂苷Rb1含量[J]. 中国药业, 2009, 18(10): 44-45 |
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| 作者姓名： | 楼晓峰 胡献跃 方肖庆 郑望升 黄秀清 |
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| 作者单位： | 浙江迪耳药业有限公司,浙江,金华,321016 |
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| 摘 要： | 目的建立测定稳心胶囊中三七含量的高效液相色谱（HPLC）法。方法色谱柱为C18柱（150mm×4．6mm，5μm），流动相为乙腈-0．1％磷酸溶液（30：70），检测波长为203nm。结果人参皂苷Rb，质量浓度在30．6～153μg／mL范围内与峰面积呈良好的线性关系（r=0．9997），方法加样平均回收率为99．31％，RSD为0．34％（n=6）。结论HPLC法准确、简便快捷、重现性好，适用于稳心胶囊中三七的含量测定和质量控制。
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| 关 键 词： | 三七 人参皂苷Rb1 含量测定 高效液相色谱法 |
Determination of Ginsenoside Rb1 in Radix et Rhizoma Notoginseng in Wenxin Capsule by HPLC |
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| Lou Xiaofeng,Hu Xianyue,Fang Xiaoqing,Zheng Wangsheng,Huang Xiuqing. Determination of Ginsenoside Rb1 in Radix et Rhizoma Notoginseng in Wenxin Capsule by HPLC[J]. China Pharmaceuticals, 2009, 18(10): 44-45 |
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| Authors: | Lou Xiaofeng Hu Xianyue Fang Xiaoqing Zheng Wangsheng Huang Xiuqing |
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| Affiliation: | ( Zhejiang Dier Pharmaceutical Co., Ltd., Jinhua, Zhejiang, China 321016) |
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| Abstract: | Objective To determine the ginsenoside Rb1 content in Radix et rhizoma notoginseng in Wenxin Capsule. Methods The HPLC method was developed for the quantitative analysis of ginsenoside Rbl. The separation was performed on the column of C18（150 mm ×4.6 mm, 5 μm）. The mobile phase was acetonitrile-0. 1% phosphoric acid solution（30 ： 70）, the detection wavelength was 203 nm. Results The linear range of gin- senoside RhL was in 30.6 - 153 μg/mL（r=0. 9997）, the average recovery rate was 99.31%, RSD was 0. 34% （n=6）. Conclusion The method is accurate, simple and fast. It can he used for the content determination and the quality control of ginsenoside Rb1 in Radix et rhizoma notoginseng in Wenxin Capsule. |
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| Keywords: | Radix et rhizoma notoginseng ginsenoside Rhl eontent determination HPLC |
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