Supersensitivity of cortical neurones of the rat to acetylcholine and L-glutamate following chronic morphine treatment |
| |
| Authors: | M Satoh W Zieglgänsberger A Herz |
| |
| Institution: | (1) Abteilung Neuropharmakologie, Max-Planck-Institut für Psychiatrie, Kraepelinstrasse 2, D-8000 München 40, Federal Republic of Germany |
| |
| Abstract: | Summary The effect of microelectrophoretically applied L-glutamate and acetylcholine on discharge activity of cortical neurones was studied in naive and in morphine-tolerant/dependent rats. The thresholds for increase in discharge activity elicited by these 2 putative neurotransmitters were 3 times lower in the tolerant/dependent rats than in the naive rats, indicating the development of supersensitivity. |
| |
| Keywords: | Cortical neuronal activity L-Glutamate" target="_blank">L-Glutamate Acetylcholine Chronic morphine treatment Supersensitivity |
| 本文献已被 SpringerLink 等数据库收录！ |
