|
|||||
|
|
| Apoptosis in Primary Oral Squamous Cell Carcinomas without Lymph Node Metastases | |
| 作者姓名： | 严志 汪国民 谢志勇 张汉东 |
| 作者单位： | Medical Cosmetic Surgery Center，Wuhan First Hospital (International)，Wuhan 430030，China，Medical Cosmetic Surgery Center，Wuhan First Hospital (International)，Wuhan 430030，China，Hubei Health Care of Women and Children Hospital，Wuhan 430070，China，Center of Stomatology，Union Hospital，Tongji Medical College，Huazhong University of Science and Technology，Wuhan 430022，China |
| 摘 要： | In recent years, studies of the significance ofapoptosis or programmed cell death represent a bi ologically important field of research that has at tracted great attention. Tumor progression is char acterized by the imbalance between cell prolifera tion and apoptosis. Recently, in patients withtumors at various sites, the apoptotic index (AI)has been shown to correlate with various histologicparameters, biologic parameters, and patient sur vival.In this study, we have i… |
| 关 键 词： | 原发口腔鳞状细胞癌 淋巴结 凋落现象 恶化程度 |
| 收稿时间： | 12 September 2003 |
Apoptosis in primary oral squamous cell carcinomas without lymph node metastases |
|
| Yan Zhi,Wang Guomin,Xie Zhiyong,Zhang Handong.Apoptosis in Primary Oral Squamous Cell Carcinomas without Lymph Node Metastases[J].Journal of Zuazhong University of Science and Technology: Medical Edition,2005,25(1):109-110. | |
| Authors: | Yan Zhi Wang Guomin Xie Zhiyong Zhang Handong |
| Institution: | 1. Medical Cosmetic Surgery Center, Wuhan First Hospital International, Wuhan 430030, China 2. Hubei Health Care of Women and Children Hospital, Wuhan 430070, China 3. Center of Stomatology , Union Hospital, Tongji Medical College, Huazhong University of Science and Technology,Wuhan 430022, China |
| Abstract: | The apoptosis in primary oral squamous cell carcinomas (OSCCs) without lymph node (LN) metastases and its relation with clinical stages and pathological grades was investigated. The terminal deoxynucleotidyl trasferase (TdT)-mediated dUTP nick end labeling (TUNEL) was used to detect the apoptotic cells in 15 cases of OSCCs. The percentage of apoptotic cells among tumor cells were calculated as apoptotic index (AI). The results showed that in all 15 cases of OSCCs, apoptotic cells could be visualized by TUNEL with AI ranging from 0.03 to 0.92 (average 0.32). AI was significantly negatively correlated with pathological grades (P<0.05). It was concluded that the apoptotic rate was related to the malignant degree of OSCCs without LN metastases. |
| Keywords: | carcinoma squamous cell apoptosis TUNEL |
| 本文献已被 CNKI 万方数据 SpringerLink 等数据库收录！ | |