抗结核药物肝损害203例分析

目的：探讨结核药物对结核患的肝损害有关问题。方法：对2000－2001年上半年住院应用抗结核药物致肝损害的203例患进行回顾性分析。结果：抗结核药肝损害高发年龄在19－59岁（80．3％），消化道症状出现和肝功能改变发生在抗结核治疗2周之内占90．1％。轻不停用抗结核药物而加用保肝治疗，重停用抗结核药物加强保肝治疗，19例好转，182例恢复正常，2例自动放弃治疗。结论：掌握抗结核药物副作用种类，频率，时间和防治对策，不仅能够及时，有效的判断是何药物引起的副作用，并调整抗结核治疗方案等，确保抗结核治疗顺利完成，而且还可及时发现，处理这些严重副作用，挽救患生命。

The study of 203 patients with hepatic lesion caused by antituberculotic drugs

Objective:To investigate some problems related to the liver lesion caused by antituberculotic drugs Methods:Two hundred and three patients with liver lesions caused by antituberdotic drugs,who hospitalized in the 2000 year and the first half of the 2001 year were reviewed Results:The patients aged from 19 to 59 year(80 3%) have a high incidence of the liver lesion caused by antituberclolis drugs.The symptoms of digestive system and liver functional lesion occurred within two weeks(90 0%).After stopping these drugs and taking the protective liver therapy,19 cases improved,182 cases recovered completely,and 2 case gave up the treatment Conclusion:To elucieite types,frequence,occurrence,prevention and care of the side effects of antituberdotic drugs will not only be able to identify timely and effectively which drug cause the side effects,and to adjust the therapy successfully,but also be able to find out and treat these serious side effects instantly to save the patients'life