肝硬化患者血清瘦素与胰岛素抵抗的关系

目的 探讨肝硬化患者血清瘦素水平的变化情况和影响因素，及其与胰岛素抵抗的关系。方法 选择肾功能正常的43例肝硬化患者和30例与其在性别、年龄和体重指数（BMI）相匹配的时照者，应用放免法测定血清瘦素。同时测定肝肾功能、血糖、血脂、胰岛素和C-肽等指标，并测量其身高、体重，计算BMI。结果 肝硬化患者血清瘦素水平同比对照组相比差异不显著；肝硬化组与对照组血清瘦素水平女性均高于男性；肝硬化患者血清瘦素水平与BMI、胰岛素和C-肽呈正相关，与胰岛素抵抗指数呈负相关；不同肝功能分级的肝硬化患者间血清瘦素水平差异不显著。结论 肝硬化患者血清瘦素水平存在性别差异。瘦素水平不能作为评价肝硬化严重程度的指标。瘦素与肝硬化患者的胰岛素抵抗相关。

Study of the Relationship Between Serum Leptin with Insulin Resistance in Cirrhosis

Objective To determine serum leptin levels in cirrhosis ,find its influence factors,and study the relationship between serum leptin with insulin resistance in cirrhosis.Methods We used a radioimmunoassy to determine serum leptin concentrations in 43 cirrhotic patients with normal renal function and 30 controls matched for gender,age and body mass index(BMI).Their liver function,renal function, blood glucose blood lipid,profile ,insulin ,C-peptide ,height ,weight and BMI were also mgasured. Results There was no significant difference in the level of leptin of the cirrhotic patients and the controls. The levels of leptin in women were significantly higher than that of men both in the cirrhotic patients and the controls. The level of serum leptin in the cirrhosis was positive relevant to BMI, insulin,C-peptide and negative relevant to insulin resistance index .There was no significant difference in different Child-Pugh class of cirrhosis.Conclusion There is a gender difference in serum leptin levels in cirrhosis.Leptin can not be a index of evaluating liver function for cirrhosis.Leptin is correlated with insulin resistance of cirrhosis.