| 卡马西平、托吡酯与丙戊酸钠治疗102例脑炎继发癫痫疗效分析 |
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| 引用本文： | 周智慧,肖争,王学峰,晏勇.卡马西平、托吡酯与丙戊酸钠治疗102例脑炎继发癫痫疗效分析[J].重庆医学,2010,39(21). |
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| 作者姓名： | 周智慧 肖争 王学峰 晏勇 |
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| 作者单位： | 重庆医科大学附属第一医院神经内科,400016;重庆医科大学附属第一医院神经内科,400016;重庆医科大学附属第一医院神经内科,400016;重庆医科大学附属第一医院神经内科,400016 |
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| 摘 要： | 目的分析卡马西平(CBZ)、托吡酯(TPM)与丙戊酸钠缓释片(VPA)对脑炎继发癫痫(SEVE)的疗效及不良反应。方法回顾性分析1998~2008年102例脑炎继发癫痫患者病历资料,根据不同的癫痫发作类型、患者年龄和性别,分组评价CBZ、TPM和VPA治疗12个月后的疗效,并分析药物不良反应。结果 3种抗癫痫药的总有效率及完全控制率差异无统计学意义;CBZ对部分性发作的控制率为62.50%及总有效率为100.00%明显高于部分性继发全面强直阵挛发作的40.00%及64.00%,VPA和TPM对各型发作的疗效差异无统计学意义;3种药物对不同性别、不同年龄组的疗效差异无统计学意义。结论在单药治疗时,CBZ对部分性发作的疗效良好,TPM、VPA适用于脑炎继发癫痫的各型发作,且TPM不良反应更少。
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| 关 键 词： | 卡马西平 托吡酯 丙戊酸钠缓释片 脑炎继发癫痫 |
Effects analysis of carbamazepine,topiramate and sodium valproate on treating secondary epilepsy after viral encephalitis in 102 cases |
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| ZHOU Zhi-hui,XIAO Zheng,WANG Xue-feng,et al..Effects analysis of carbamazepine,topiramate and sodium valproate on treating secondary epilepsy after viral encephalitis in 102 cases[J].Chongqing Medical Journal,2010,39(21). |
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| Authors: | ZHOU Zhi-hui XIAO Zheng WANG Xue-feng |
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| Institution: | ZHOU Zhi-hui,XIAO Zheng,WANG Xue-feng,et al.(Department of Neurology,First Affiliated Hospital of Chongqing Medical University,Chongqing 400016,China) |
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| Abstract: | Objective To analyze the effects and side reactions of carbamazepine(CBZ),topiramate(TPM) and sodium valproate sustained release tablets(VPA) on treating secondary epilepsy after viral encephalitis(SEVE).Methods A retrospective study was performed on 102 patients with SEVE in our hospital.12 months effects and side reactions for three drug-groups(CBZ,TPM and VPA) were analyzed according to different seizure type,age and sex of patients.Results In total effective rate and remission rate,there was no signific... |
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| Keywords: | carbamazepine topiramate sodium valproate sustained release tablets treating secondary epilepsy after viral encephalitis |
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