Accelerated utilization of lactate under the effect of hypoxen after intensive exercise |
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| Authors: | E V Grishina Ya V Khaustova V G Pogorelova A G Pogorelov M K Kuz’mich E I Maevskii |
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| Institution: | (1) Laboratory of Biosystems Thermodynamics and Energy, Institute of Theoretical and Experimental Biophysics, Russian Academy of Sciences, Pushchino, Russia;(2) Olifen Corporation, Moscow, Russia |
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| Abstract: | Administration of substrates of energy metabolism in combination with hypoxen (sulfur-containing oligoquinone) promoted the
increase in blood lactate concentration during maximum exercise, accelerated lactate utilization, and reduced the lactate/pyruvate
ratio during recovery. The in vivo effects are in line with hypoxen capacity to accelerate in vitro oxidation of exogenous NADH in mitochondria by the non-rotenone-dependent pathway realized with participation of cytochrome
C.
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Translated from Byulleten’ Eksperimental’noi Biologii i Meditsiny, Vol. 145, No. 2, pp. 158–161, February, 2008 |
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| Keywords: | hypoxen lactate exercise mitochondria |
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