| 维拉帕米对难治性癫大鼠的疗效及海马P-糖蛋白表达的影响 |
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| 引用本文： | 林娟霞,陈利强,孙美珍,王明正.维拉帕米对难治性癫大鼠的疗效及海马P-糖蛋白表达的影响[J].国外医学：物理医学与康复学分册,2010,5(1):21-23. |
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| 作者姓名： | 林娟霞 陈利强 孙美珍 王明正 |
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| 作者单位： | [1]山西医科大学第一临床医学院神经内科,太原030001 [2]山西医科大学神经药理教研室,太原030001 |
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| 摘 要： | 目的:观察耐药蛋白抑制剂维拉帕米对难治性癫大鼠的疗效及海马P-糖蛋白表达的影响。方法:Wistar大鼠50只,随机分为生理盐水组(NS组)、匹罗卡品组(PILO组)、卡马西平组(CBZ组)、低剂量维拉帕米组(LDV组)和高剂量维拉帕米组(HDV组),氯化锂-匹罗卡品腹腔注射制作大鼠自发性癫模型,选择耐药癫大鼠,分别给予常规或添加维拉帕米抗癫治疗,观察大鼠性发作频率及海马P-糖蛋白表达的变化。结果:与NS组相比,其它4组大鼠性发作频率增高,海马P-糖蛋白表达增强(P0.05);LDV组和HDV组大鼠的性发作频率及海马P-糖蛋白表达较PILO组和CBZ组降低(P0.05);PILO组和CBZ组大鼠性发作频率及海马P-糖蛋白表达无明显差异,LDV组和HDV组大鼠性发作频率及海马P-糖蛋白表达无明显差异。结论:添加维拉帕米治疗可明显减少难治性癫大鼠性发作频率,降低难治性癫大鼠海马P-糖蛋白的表达。
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| 关 键 词： | 难治性癫 维拉帕米 P-糖蛋白 |
Effects of Verapamil on Refractory Epilepsy and on Expression of P-glycoprotein in the Hippocampus in Rat Model |
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| LIN Juan-xia,CHEN Li-qiang,SUN Mei-zhen,WANG Ming-zheng.Effects of Verapamil on Refractory Epilepsy and on Expression of P-glycoprotein in the Hippocampus in Rat Model[J].Neural Injury and Functional Reconstruction,2010,5(1):21-23. |
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| Authors: | LIN Juan-xia CHEN Li-qiang SUN Mei-zhen WANG Ming-zheng |
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| Abstract: | Objective:To investigate the therapeutic effect of verapamil on refractory epilepsy and the effect of vrerapmil on expression of P-glycoprotein(P-gp) in the hippocampus in rat model of refractory epilepsy.Method:A rat model of spontaneous recurrent seizures(SRS) has been generated through lithium-pilocarpine lumbar injection.The SRS rats with drug resistance were selected and randomly divided into the control,the pilocarpine,the carbamazepine,the low-dose verapamil and the high-dose verapamil group.The freq... |
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| Keywords: | refractory epilepsy verapamil P-glycoprotein |
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