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| Ⅰ期子宫内膜癌中p21ras的表达与DNA含量的研究 | |
| 引用本文： | 李秀杰,李玉华,孙继英. Ⅰ期子宫内膜癌中p21ras的表达与DNA含量的研究[J]. 吉林大学学报(医学版), 1999, 25(6): 727-728 |
| 作者姓名： | 李秀杰 李玉华 孙继英 |
| 作者单位： | 1. 白求恩医大第三临床学院血液肿瘤科,长春,130031 2. 厦门中山医院 3. 长春市防疫站 |
| 摘 要： | 目的：探讨Ⅰ期子宫内膜癌ｐ２１ｒａｓ 表达及ＤＮＡ 含量。方法：ＡＢＣ免疫组化法及流式细胞术。结果：随组织学分级增高ｐ２１ｒａｓ表达率增高（Ｐ＜ ０．０５），ＤＮＡ 异倍体率亦增加（Ｐ＜ ０．０５）。异倍体子宫内膜癌中ｐ２１ｒａｓ阳性表达率（８２．３５％ ）较二倍体子宫内膜癌（３０．７７％ ）高（Ｐ＜ ０．０５）。结论：提示ｐ２１ｒａｓ作为子宫内膜癌预后参数的可能性，尤其是双参数同步分析将更好地评价子宫内膜癌预后 |
| 关 键 词： | 子宫内膜癌 免疫组织化学 流式细胞术 p21ras DNA |
| 修稿时间： | 1999-01-08 |
Evaluation of p21ras expression and quantitative measurement of DNA content in stage Ⅰ endometrial carcinoma |
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| Li Xiujie,Li Yuhua,Sun Jiying. Evaluation of p21ras expression and quantitative measurement of DNA content in stage Ⅰ endometrial carcinoma[J]. Journal of Jilin University: Med Ed, 1999, 25(6): 727-728 | |
| Authors: | Li Xiujie Li Yuhua Sun Jiying |
| Abstract: | Objective:To study p21ras expression and quantitative measurement of DNA content in stage Ⅰ endometrial carcinoma.Methods:ABC immunohistochemical technique and flow cytometry were used.Results:①The postivie rate of p21ras expression and DNA content obviously increased with the degree of tumor differentiation.②The positive rate of p21ras expression was higher in endometrial carcinoma with DNA aneuplioid than in that with DNA diploid ( P <0 05).Conclusion:Our data indicate that it is possible for p21ras to be a new prognostic parameter.Expecially,analysis of two parameters (p21ras expression and DNA content) will provide an effective evaluation for the prognosis of stage Ⅰ endometrial carcinoma. |
| Keywords: | p21ras DNA |
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