| 内毒素诱导Kupffer细胞所致肝脏损害及S-腺苷蛋氨酸的保护机制 |
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| 引用本文： | 张钊,龚建平. 内毒素诱导Kupffer细胞所致肝脏损害及S-腺苷蛋氨酸的保护机制[J]. 国际外科学杂志, 2009, 36(12). DOI: 10.3760/cma.j.issn.1673-4203.2009.12.021 |
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| 作者姓名： | 张钊 龚建平 |
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| 作者单位： | 重庆医科大学附属第二医院肝胆外科,重庆,400010;重庆医科大学附属第二医院肝胆外科,重庆,400010 |
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| 摘 要： | S-腺苷蛋氨酸(SAM)是一种存在于人体所有组织和体液中的生理活性分子,参与体内多种重要的生化反应,对调节肝细胞再生、分化以及肝细胞对各种损伤的敏感程度都是非常重要的.SAM对肝脏的这些作用是通过多种途径实现的,现已证实S-腺苷蛋氨酸及其代谢物methyhhioade-nosine(MTA)能阻断脂多糖(LPS)诱导的kupffer细胞中肿瘤坏死因子α(TNF-α)的表达从而对肝脏起到保护作用.S-腺苷蛋氨酸的这些作用可能有益于LPS诱导的肝损伤的临床治疗.
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| 关 键 词： | S-腺苷蛋氨酸(SAM) kupffer细胞(KC) 脂多糖(LPS) |
Lipopolysaccharide-induced liver injury expression Kupffer cell and protection mechanisms of S-adenosylmethionine |
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| ZHANG Zhao,GONG Jian-Ping. Lipopolysaccharide-induced liver injury expression Kupffer cell and protection mechanisms of S-adenosylmethionine[J]. International Journal of Surgery, 2009, 36(12). DOI: 10.3760/cma.j.issn.1673-4203.2009.12.021 |
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| Authors: | ZHANG Zhao GONG Jian-Ping |
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| Abstract: | S-adenosylmethionine(SAM) is a physiologically active molecule in all the organizations and the human body fluids, and it is important to participate in a variety of biochemical reactions, the regulation of liver regeneration, liver cells differentiation and various sensitivity of the injury. The SAM affects the liver through a variety of ways. It is confirmed that the SAM and MTA can block the LPS-induced TNF-α of Kupffer cells to protect the liver. In a word, S-adenosylmethionine may be beneficial to LPS-induced liver in-jury in clinical treatment. |
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| Keywords: | s-adennsylmethionine(SAM) kupffer cell(KC) lipopolysaccharide(LPS) |
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