抗心磷脂抗体与缺血性脑血管病的关系

目的 :研究抗心磷脂抗体 (ACA) ,在脑血栓患者的病程演变中的变化情况、与远期疗效的关系 ,旨在探讨ACA与血栓性脑梗死的关系。方法 :应用酶联免疫吸附试验 (ELISA)检测空腹血清中ACA的含量。结果 :脑梗死组的ACA阳性率远较短暂脑缺血组、脑出血组、非脑血管病组、正常对照组为高 ,均有显著性差异 (P<0 0 1)。随时间变化 ,脑梗死组ACA阳性率逐渐减少 ,差异有显著性 (P <0 .0 1)。脑梗死组ACA阳性者 2年内再发脑梗死较ACA阴性者再发率为高 ,差异有显著性 (P <0 .0 1)。结论 :ACA与脑梗死的发生、发展以及再发脑梗死的关系密切 ,可作为病情转归的指标 ,也可作为高危人群早期预防干预的参考

A Study on the Relationship of Anti-cardiolipin Antibody with Ischemic Cerebrovascular Disorders

Objective: To study 1) the dynamic changes of anti cardiolipin antibody (ACA) of cerebral thrombosis sufferers (CTS) in the course of disease evolution; 2) the relationship between the ACA changes and the forward curative effect; 3) the difference of ACA changes between encephalorrhagia patients and normal people; 4) the relationship between ACA and cerebral infarction. Methods: Subjects were divided into 4 groups: cerebral infaction (CIN),encephalorrhagia patients (ERP), transient ischemic attack (TIA),and normal people (NP)as controls. Fasting serum ACA content in different groups was examined with ELISA. Results: The positive reaction rate of ACA in CIN group was far higher than those in the groups of TIA, ERP, NP, and that of non cerebrovascular disease patients hospitalized in the same period (NCP). The differences were significant (P<0 01). With time passing, the positive reaction rate of ACA in the CIN group dropped gradually. The difference was significant (P<0 01).In CIN group, the 2 year relapse rate of cerebral infarction in patients with ACA positive reaction was higher than that of patients with ACA negative reaction. The difference was significant (P<0 01).Conclusion: ACA has close relationship to the occurrence, progress and relapse of cerebral infarction. It can be taken as an index to reflect the patient's condition, and a reference of early decision of preventive interference to the high risk people.