| 保留大鼠半肝动脉血供肝血流安全阻断时限的实验研究 |
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| 引用本文： | 穆振国,王新伟,王洪远,梁静雅,李建新,张林. 保留大鼠半肝动脉血供肝血流安全阻断时限的实验研究[J]. 济宁医学院学报, 2011, 0(5): 312-315 |
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| 作者姓名： | 穆振国 王新伟 王洪远 梁静雅 李建新 张林 |
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| 作者单位： | 日照市中医医院; |
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| 摘 要： | 目的探讨门静脉自然转流及非转流情况下保留半肝动脉血供肝血流阻断的安全时限。方法将实验用雄性Wistar大鼠随机分为A、B、C组。A组保留肝左、肝中动脉血供及尾状叶动脉、门静脉血供（约占全肝5%）,夹闭肝左、肝中叶门静脉,结扎肝右叶肝蒂,到预定阻断时相点,恢复肝脏灌流,切除肝右叶及尾状叶,24h后检测ALT、肝脏HE染色（细胞核）阳性面积的平均百分数及术后7d存活率。B组不保留尾状叶动脉、门静脉血供,其他与A组相同。C组完全阻断肝脏入肝血流,肝切除方式及检测指标与A组相同。结果在A、B、C 3组中,A组的阻断形式对肝脏的损害最轻,B组次之,C组最重。A/100、B/40与C/20损害程度相当。结论大鼠门静脉转流下保留半肝动脉血供入肝血流阻断的安全时限是100min,单纯保留半肝动脉血供入肝血流阻断组的安全时限是40min。
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| 关 键 词： | 肝切除术 保留半肝动脉血供 肝血流阻断 安全时限 Wistar大鼠 |
Research on tolerance limit of rats to hepatic inflow oculusion with half-hepatic artery supply retained |
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| MU Zhen-guo,WANG Xin-wei,WANG Hong-yuan,et al. Research on tolerance limit of rats to hepatic inflow oculusion with half-hepatic artery supply retained[J]. Jounal of Jinning Medical College, 2011, 0(5): 312-315 |
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| Authors: | MU Zhen-guo WANG Xin-wei WANG Hong-yuan et al |
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| Affiliation: | MU Zhen-guo,WANG Xin-wei,WANG Hong-yuan,et al(General Surgery Department,Rizhao Hospital of Traditional Chinese Medicine,Rizhao 276800,China) |
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| Abstract: | Objective To study the tolerance limit of rats to hepatic inflow occlusion with half-hepatic artery supply retained and together with portal vein blood bypass or not.Methods Rats were randomly divided into three groups(group A,B and C).The left and middle hepatic artery supply were remained in both A and B group,and caudate lobe supply(Including part of artery and portal vein supply of caudate lobe,about 5% in total hepatic blood supply) was together remained in the A group while not remained in the B group... |
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| Keywords: | Rats Hepatic inflow occlusion with half-hepatic artery supply Tolerance limit |
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