| 氨噻肟酸乙酯的合成 |
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| 引用本文： | 胡艾希,徐娟娟,伍小云. 氨噻肟酸乙酯的合成[J]. 中国医药工业杂志, 2006, 37(4): 229-230 |
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| 作者姓名： | 胡艾希 徐娟娟 伍小云 |
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| 作者单位： | 1. 华南理工大学化工与能源学院,广东,广州,510640;湖南大学化学化工学院,湖南,长沙,410082
2. 湖南大学化学化工学院,湖南,长沙,410082 |
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| 摘 要： | 4-氯-3-氧代丁酸乙酯经肟化、与硫脲环合制得2-（2-氨基-4-噻唑基）-2-羟基亚胺基乙酸乙酯，在相转移催化剂溴化四乙铵作用下用硫酸二甲酯醚化制得氨噻肟酸乙酯，总收率46％。
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| 关 键 词： | 氨噻肟酸乙酯 头孢菌素 中间体 合成 |
| 文章编号： | 1001-8255（2006）04-0229-02 |
| 收稿时间： | 2005-04-07 |
| 修稿时间： | 2005-04-07 |
Synthesis of Ethyl Methylaminothiazolyloximate |
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| HU Ai-Xi,XU Juan-Juan,WU Xiao-Yun. Synthesis of Ethyl Methylaminothiazolyloximate[J]. , 2006, 37(4): 229-230 |
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| Authors: | HU Ai-Xi XU Juan-Juan WU Xiao-Yun |
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| Affiliation: | 1. School of Chemical and Energy Engineering, South China University of Technology, Guangzhou 510640; 2. College of Chemistry and Chemical Engineering, Hunan University, Changsha 410082 |
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| Abstract: | Ethyl methylaminothiazolyloximate was synthesized from ethyl 4-chloro-3-oxobutyrate by oximation and cyclization with thiourea to give ethyl 2-(2-aminothiazol-4-yl)-2-hydroxyiminoacetate followed by etherification with (CH3) 2SO4 in presence of tetrabutylammonium bromide with an overall yield of 46%. |
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| Keywords: | ethyl methylaminothiazolyloximate cephalosporin intermediate synthesis |
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