| 白介素-10与银屑病 |
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| 引用本文： | 权晟,杨森,张学军. 白介素-10与银屑病[J]. 国际皮肤性病学杂志, 2006, 32(6): 380-382 |
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| 作者姓名： | 权晟 杨森 张学军 |
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| 作者单位： | 230022,合肥,安徽医科大学皮肤病研究所、第一附属医院皮肤科 |
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| 摘 要： | 银屑病是一种常见的红斑丘疹鳞屑性皮肤病,免疫调节异常是其重要的致病机制之一。白介素-10是一种具有多种免疫调节作用的Th2型细胞因子,能够抑制角质形成细胞过度增殖和分化,促进Ⅰ型细胞因子模式向Ⅱ型转变,减少银屑病皮损T细胞浸润。临床试验证实,IL-10具有显著的抗银屑病作用,且无严重毒副作用,有希望成为治疗银屑病的一种新手段。
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| 关 键 词： | 银屑病 白细胞介素-10 |
| 收稿时间： | 2006-01-26 |
| 修稿时间： | 2006-01-26 |
Interleukin-1o and psoriasis |
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| QUAN Cheng,YANG Sen,ZHANG Xue-Jun. Interleukin-1o and psoriasis[J]. International Journal of Dermatology and Venereology, 2006, 32(6): 380-382 |
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| Authors: | QUAN Cheng YANG Sen ZHANG Xue-Jun |
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| Abstract: | Psoriasis is a common chronic inflammatory skin disease, and immunoregulation abnormality is one of the important factors involved in its pathogenesis. Interleukin-10 is a pluripotent cytokine with major impacts on several immune responses, including inhibiting keratinocyte proliferation and differentiation, promoting type 1/ type 2 cytokine balance shift, decreasing cutaneous T cell infiltration. The antipsoriatic activity of IL-10 has been demonstrated in clinical trials. And it could be a promising candidate for the treatment of psoriasis. |
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| Keywords: | Psoriasis Interleukin-10 |
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