Infusion of the serotonin1B (5-HT1B) agonist CP-93,129 into the parabrachial nucleus potently and selectively reduces food intake in rats |
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| Authors: | M. D. Lee Vincent J. Aloyo Steven J. Fluharty K. J. Simansky |
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| Affiliation: | (1) Department of Pharmacology, MCP-Hahnemann School of Medicine, Allegheny University of the Health Sciences, 3200 Henry Avenue, Philadelphia, PA 19129, USA, US;(2) Department of Animal Biology and Pharmacology and the Institute of Neurological Sciences, University of Pennsylvania Schools of Medicine and Veterinary Medicine, 3800 Spruce Street, Philadelphia, PA 19104, USA, US |
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| Abstract: | Unilateral infusion of the selective 5-HT1B agonist, CP-93,129 (3-(1,2,5,6-tetrahydropyrid-4-yl) pyrrolo[3,2-b]pyrid-5-one) into the parabrachial nucleus (PBN) of the pons reduced food consumption by rats. The hypophagia was dose-related (ED50 ≈ 1 nmol) and associated with fewer observations of feeding and more periods of inactivity. Water intake, grooming and exploratory activity were unaffected. CP-93,129 also decreased food intake when injected into the hypothalamic paraventricular nucleus, but this action was 50-fold less potent than administration into the PBN. Autoradiography demonstrated 5-HT1B sites in the PBN; this binding was displaced by CP-93,129. The results implicate parabrachial 5-HT1B receptors in mediating serotonergic enhancement of satiation. Received: 11 November 1997/Final version: 20 November 1997 |
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| Keywords: | CP-93 129 Serotonin 5-HT1B receptor Parabrachial nucleus Paraventricular nucleus Feeding Satiety |
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