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Indenone derivatives: a novel template for peroxisome proliferator-activated receptor gamma (PPARgamma) agonists |
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| Authors: | Ahn Jin Hee Shin Mi Sik Jung Sun Ho Kang Seung Kyu Kim Kwang Rok Rhee Sang Dal Jung Won Hoon Yang Sung Don Kim Seung Jun Woo Joo Rang Lee Jeong Hyung Cheon Hyae Gyeong Kim Sung Soo |
| Affiliation: | Bioorganic Science Division, Korea Research Institute of Chemical Technology, Yuseong-Gu, Daejeon, 305-600, Republic of Korea. |
| Abstract: | Agonists of peroxisome proliferator-activated receptor gamma (PPAR gamma) are of interest as a treatment for diabetes, which prompted the identification of a new class of non-TZD PPAR gamma agonist. Moreover, compound 14c has displayed the most active agonistic activity with an EC50 value of 50 nM, in addition to exhibiting a new binding mode in the X-ray cocrystal structure. |
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